用 12.8 MeV 质子辐照 Ca 靶产生的 Sc 的改进分离方案。
Improved separation scheme for Sc produced by irradiation of Ca targets with 12.8 MeV protons.
机构信息
Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna 141980, Russian Federation; Department of High-Energy Chemistry and Radioecology, D. Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russian Federation; Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada.
Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada; Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
出版信息
Nucl Med Biol. 2022 Jan-Feb;104-105:22-27. doi: 10.1016/j.nucmedbio.2021.11.002. Epub 2021 Nov 11.
INTRODUCTION
Sc is of great interest as a positron emission tomography (PET) radionuclide due to its suitable nuclear characteristics: E = 1.47 MeV, branching ratio 94.3% and convenient half-life of 3.97 h. Here, Sc was produced via the widely used reaction Ca (p,n)Sc using natural calcium as a target.
METHODS
The irradiation was performed at TRIUMF using the 13 MeV cyclotron. The separation consisted of a combination of DGA branched resin and Dowex 50Wx8 (200-400 mesh). The distribution coefficients of Sc on Dowex 50Wx8 (NH form, 200-400 mesh) with ammonium α-hydroxyisobutyrate (pH = 4.8) medium were determined in this study.
RESULTS AND CONCLUSION
The tested scheme allows both a reliable separation of Sc from the target material as well as from the other competitive metals and a final fraction with high specific activity. The achieved radiochemical yield was 95 ± 3%.
简介
由于其合适的核特性，Sc 作为正电子发射断层扫描（PET）放射性核素具有很大的研究意义：E=1.47 MeV，分支比为 94.3%，半衰期为 3.97 h。在此，Sc 是通过广泛使用的 Ca（p，n）Sc 反应，以天然钙作为靶材来产生的。
方法
该辐照是在 TRIUMF 利用 13 MeV 回旋加速器进行的。分离由 DGA 支化树脂和 Dowex 50Wx8（200-400 目）的组合组成。本研究测定了 Sc 在 Dowex 50Wx8（NH 形式，200-400 目）与铵 α-羟基异丁酸（pH=4.8）介质中的分配系数。
结果与结论
所测试的方案不仅可以可靠地将 Sc 从靶材料以及其他竞争金属中分离出来，还可以得到具有高比活度的最终馏分。获得的放射化学产率为 95±3%。
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