Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna 141980, Russian Federation; Department of High-Energy Chemistry and Radioecology, D. Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russian Federation; Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada.
Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada; Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
Nucl Med Biol. 2022 Jan-Feb;104-105:22-27. doi: 10.1016/j.nucmedbio.2021.11.002. Epub 2021 Nov 11.
Sc is of great interest as a positron emission tomography (PET) radionuclide due to its suitable nuclear characteristics: E = 1.47 MeV, branching ratio 94.3% and convenient half-life of 3.97 h. Here, Sc was produced via the widely used reaction Ca (p,n)Sc using natural calcium as a target.
The irradiation was performed at TRIUMF using the 13 MeV cyclotron. The separation consisted of a combination of DGA branched resin and Dowex 50Wx8 (200-400 mesh). The distribution coefficients of Sc on Dowex 50Wx8 (NH form, 200-400 mesh) with ammonium α-hydroxyisobutyrate (pH = 4.8) medium were determined in this study.
The tested scheme allows both a reliable separation of Sc from the target material as well as from the other competitive metals and a final fraction with high specific activity. The achieved radiochemical yield was 95 ± 3%.
由于其合适的核特性，Sc 作为正电子发射断层扫描（PET）放射性核素具有很大的研究意义：E=1.47 MeV，分支比为 94.3%，半衰期为 3.97 h。在此，Sc 是通过广泛使用的 Ca（p，n）Sc 反应，以天然钙作为靶材来产生的。
该辐照是在 TRIUMF 利用 13 MeV 回旋加速器进行的。分离由 DGA 支化树脂和 Dowex 50Wx8（200-400 目）的组合组成。本研究测定了 Sc 在 Dowex 50Wx8（NH 形式，200-400 目）与铵 α-羟基异丁酸（pH=4.8）介质中的分配系数。
所测试的方案不仅可以可靠地将 Sc 从靶材料以及其他竞争金属中分离出来，还可以得到具有高比活度的最终馏分。获得的放射化学产率为 95±3%。
