Lowis Carsten, Ferguson Simon, Paulßen Elisabeth, Hoehr Cornelia
Faculty of Chemistry and Biotechnology, FH Aachen, Campus Jülich, 52428, Jülich, Germany.
Life Sciences Division, TRIUMF, Vancouver, BC V5Y 1T5, Canada.
Appl Radiat Isot. 2021 Jun;172:109675. doi: 10.1016/j.apradiso.2021.109675. Epub 2021 Mar 16.
In order to use new and promising radiometals for molecular imaging, it is important that they can be obtained as inexpensively and easily as possible. This often requires a cyclotron with solid target hardware or a radionuclide generator, which are not widely available for rarely used radionuclides. Here, we investigate the improved production of Sc with a siphon-style liquid target system and compare to our previous work with a simple liquid target. A metal salt solution with a high concentration of natural abundance Ca(NO) (0.14 g/cm) was irradiated with a medical cyclotron (12 MeV protons; 20 μA). Sc was produced via the Ca(p,x)Sc reaction. As the pressure increase during irradiation was reduced in the siphon-style target, it was possible to irradiate with a higher proton beam current (20 μA) than with the simple liquid target system (7.9 μA). In addition, the saturation yield per μA of Sc was increased by a factor of 3.18 ± 0.05 (6.2 ± 0.1 MBq/μA with the siphon target versus 1.94 ± 0.08 MBq/μA with the simple target). This results in an overall increase in Sc activity by a factor of 11.
为了将新型且有前景的放射性金属用于分子成像，重要的是要尽可能以低成本且简便的方式获得它们。这通常需要配备固体靶硬件的回旋加速器或放射性核素发生器，但对于稀有使用的放射性核素而言，这些设备并不广泛可得。在此，我们研究了利用虹吸式液体靶系统改进钪的生产，并与我们之前使用简单液体靶的工作进行比较。用医用回旋加速器（12兆电子伏质子；20微安）照射含有高浓度天然丰度硝酸钙（0.14克/立方厘米）的金属盐溶液。通过钙（质子，X）钪反应生成钪。由于虹吸式靶在照射期间压力增加有所降低，因此能够以比简单液体靶系统（7.9微安）更高的质子束电流（20微安）进行照射。此外，钪每微安的饱和产率提高了3.18±0.05倍（虹吸靶为6.2±0.1兆贝可/微安，而简单靶为1.94±0.08兆贝可/微安）。这使得钪的活度总体提高了11倍。
