Eiden J, Lederman H M, Vonderfecht S, Yolken R
J Virol. 1986 Feb;57(2):706-8. doi: 10.1128/JVI.57.2.706-708.1986.
Rotaviruses are common causes of diarrhea in animals and humans. Little is known, however, about the components of the host response to these viruses. Rotavirus infection was studied in athymic mice experimentally infected with murine rotavirus. Neonatal T-cell-deficient mice experienced a self-limited gastrointestinal infection which was identical to that observed in age-matched immunocompetent mice. Adult T-cell-deficient seronegative mice and age-matched normal mice showed a similar extent of resistance to symptomatic rotavirus infection. In both cases, the infection was resolved without the generation of antirotavirus antibody. These studies indicate that host defense against murine rotavirus requires neither functional T-lymphocytes nor specific antiviral antibody.
轮状病毒是动物和人类腹泻的常见病因。然而，对于宿主针对这些病毒的反应组成部分却知之甚少。在实验性感染鼠轮状病毒的无胸腺小鼠中对轮状病毒感染进行了研究。新生T细胞缺陷小鼠经历了一种自限性胃肠道感染，这种感染与在年龄匹配的免疫 competent 小鼠中观察到的感染相同。成年T细胞缺陷血清阴性小鼠和年龄匹配的正常小鼠对有症状的轮状病毒感染表现出相似程度的抵抗力。在这两种情况下，感染都得以解决，且未产生抗轮状病毒抗体。这些研究表明，宿主对鼠轮状病毒的防御既不需要功能性T淋巴细胞也不需要特异性抗病毒抗体。 （注：“immunocompetent”常见释义为“有免疫能力的” ，这里可能是文档录入有误，推测应该是“immunocompetent” ，按照准确意思翻译了整段内容。）
