轮状病毒特异性细胞毒性T淋巴细胞与感染不同轮状病毒血清型的靶细胞发生交叉反应。
Rotavirus-specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes.
作者信息
Offit P A, Dudzik K I
机构信息
Department of Medical Microbiology, Stanford University School of Medicine, California 94305.
出版信息
J Virol. 1988 Jan;62(1):127-31. doi: 10.1128/JVI.62.1.127-131.1988.
Abstract
Splenocytes from adult C57BL6 (H-2b) mice orally inoculated with nonmurine rotaviruses lysed syngeneic rotavirus-infected target cells. Cytotoxic T lymphocytes (CTLs) were responsible for this cytotoxic activity. Cytotoxic activity was (i) detected 7 days after primary oral inoculation; (ii) not detected in uninoculated animals; (iii) specific for rotavirus-infected target cells; (iv) eliminated by treatment with Thy 1.2-specific immunoglobulin M and complement; and (v) restricted at H-2Db. In addition, rotavirus-specific CTLs cross-reacted with target cells infected with different human or animal rotavirus serotypes. Heterotypic protection against rotavirus challenge may be mediated by cross-reactive CTLs.
摘要
用非鼠类轮状病毒经口接种的成年C57BL6（H-2b）小鼠的脾细胞可裂解同基因的轮状病毒感染的靶细胞。细胞毒性T淋巴细胞（CTL）负责这种细胞毒性活性。细胞毒性活性表现为：（i）初次经口接种7天后可检测到；（ii）未接种的动物中未检测到；（iii）对轮状病毒感染的靶细胞具有特异性；（iv）用Thy 1.2特异性免疫球蛋白M和补体处理后消除；（v）受H-2Db限制。此外，轮状病毒特异性CTL与感染不同人或动物轮状病毒血清型的靶细胞发生交叉反应。针对轮状病毒攻击的异型保护可能由交叉反应性CTL介导。
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本文引用的文献
1
THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT.大鼠淋巴细胞的再循环途径
Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:257-82. doi: 10.1098/rspb.1964.0001.
2
Type-specific reovirus antiserum blocks the cytotoxic T-cell-target cell interaction: evidence for the association of the viral hemagglutinin of a nonenveloped virus with the cell surface.型特异性呼肠孤病毒抗血清阻断细胞毒性T细胞与靶细胞的相互作用：无包膜病毒的病毒血凝素与细胞表面相关的证据。
Infect Immun. 1981 Feb;31(2):646-9. doi: 10.1128/iai.31.2.646-649.1981.
3
Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice.抗原致敏小鼠肠道黏膜中细胞毒性效应细胞的非特异性募集。
J Exp Med. 1984 Dec 1;160(6):1931-6. doi: 10.1084/jem.160.6.1931.
4
Response of mice to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque reduction neutralization.通过放射免疫测定、放射免疫沉淀和蚀斑减少中和试验评估小鼠对牛源或灵长类源轮状病毒的反应。
Infect Immun. 1983 Oct;42(1):293-300. doi: 10.1128/iai.42.1.293-300.1983.
5
Recovery from lethal herpes simplex virus type 1 infection is mediated by cytotoxic T lymphocytes.从致死性1型单纯疱疹病毒感染中恢复是由细胞毒性T淋巴细胞介导的。
Infect Immun. 1983 Jul;41(1):197-204. doi: 10.1128/iai.41.1.197-204.1983.
6
A two-year study of bacterial, viral, and parasitic agents associated with diarrhea in rural Bangladesh.一项针对孟加拉国农村地区腹泻相关细菌、病毒和寄生虫病原体的为期两年的研究。
J Infect Dis. 1980 Nov;142(5):660-4. doi: 10.1093/infdis/142.5.660.
7
Analysis of the effector functions of different populations of mucosal lymphocytes.黏膜淋巴细胞不同群体的效应功能分析。
Ann N Y Acad Sci. 1983 Jun 30;409:307-20. doi: 10.1111/j.1749-6632.1983.tb26879.x.
8
Serotypic similarity and diversity of rotaviruses of mammalian and avian origin as studied by plaque-reduction neutralization.通过蚀斑减少中和试验研究的哺乳动物和禽类来源轮状病毒的血清型相似性和多样性
J Infect Dis. 1984 May;149(5):694-702. doi: 10.1093/infdis/149.5.694.
9
10
Preferential H-2 association in cytotoxic T cell responses to SV40 tumor-associated specific antigens.
J Immunol. 1980 Apr;124(4):1888-91.
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