两种不同方法建立犬尿道成形术模型的比较：一项实验研究。
Comparison of two different methods of establishment of canine urethroplasty model: an experimental trial.
机构信息
Department of Urology, Beijing Jishuitan Hospital, No. 68, Huinanbei Road, Changping District, Beijing, 100096, China.
Beijing Research Institute of Traumatology and Orthopaedics, No. 31 Xinjiekou East Street, Xicheng District, Beijing, 100035, China.
出版信息
BMC Urol. 2021 Nov 30;21(1):165. doi: 10.1186/s12894-021-00933-1.
BACKGROUND
Graft substitute urethroplasty is recommended for patients with long segment anterior urethral stricture. The therapeutic effects of the grafts need to be validated on the animal models. Therefore the aim of this study was to compared the operative time, blood loss, intra- and post- operative complications of two different methods of establishment of canine urethroplasty model.
METHODS
Twelve Beagle dogs were randomly separated into control and experimental group using a random number table. Six animals in the control group received the conventional urethroplasty, while the other 6 in the experimental group received the modified procedures. Tube cystostomy and urethroplasty were performed in the control group. The cystostomy not the tube cystostomy were performed in the experimental group, and the testes were simultaneously removed with the scrotum. Per- and postoperative outcomes, complications were evaluated.
RESULTS
The urethroplasty were successfully performed for all dogs and all of these procedures were done by the same surgeon. The median operative time in the control and experimental groups was 186.8 min and 188.7 min respectively. The blood loss in the control and experimental groups was 40.8 ml and 45.8 ml respectively. No intraoperative complications occurred. 3 animals in the control group developed acute urinary retention after the accidental removal of suprapubic bladder tube and the cystostomy was done again. There was no occurrence of urinary retention in the experimental group. 4 animals in the control group developed the perineal hematoma, in which one animal had the urine leakage and incision infection. Perineal hematoma occurred in only one animal in the experimental group.
CONCLUSION
The occurrence of urinary retention and perineal hematoma decreased in the modified group, in which the cystostomy not the tube cystostomy were performed and the testes with the scrotum were simultaneously removed.
背景
对于长段前尿道狭窄的患者，推荐使用移植物替代尿道成形术。需要在动物模型上验证移植物的治疗效果。因此，本研究的目的是比较两种不同方法建立犬尿道成形术模型的手术时间、出血量、围手术期并发症。
方法
12 只比格犬采用随机数字表法随机分为对照组和实验组。对照组 6 只动物接受常规尿道成形术，实验组 6 只动物接受改良术式。对照组行膀胱造口术和尿道成形术，实验组不行膀胱造口术，仅行造口术，同时切除睾丸和阴囊。评估围手术期和术后结果、并发症。
结果
所有犬均成功完成尿道成形术，所有手术均由同一位外科医生完成。对照组和实验组的平均手术时间分别为 186.8 分钟和 188.7 分钟，对照组和实验组的出血量分别为 40.8 毫升和 45.8 毫升。术中无并发症发生。对照组 3 只动物因耻骨上膀胱管意外拔出导致急性尿潴留，再次行膀胱造口术。实验组无尿潴留发生。对照组 4 只动物发生会阴部血肿，其中 1 只动物发生尿漏和切口感染。实验组仅 1 只动物发生会阴部血肿。
结论
改良组（不行膀胱造口术，仅行造口术，同时切除睾丸和阴囊）术后尿潴留和会阴部血肿的发生率降低。
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