Burn Unit, Plastic and Reconstructive Surgery Department, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.
Burn Unit, Plastic and Reconstructive Surgery Department, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.
J Plast Reconstr Aesthet Surg. 2022 Mar;75(3):1048-1056. doi: 10.1016/j.bjps.2021.09.074. Epub 2021 Oct 22.
Hand burns are common injuries that can result in long-term impairment of hand function. Enzymatic debridement (ED) prevents damage to the viable dermis due to the procedure's selectivity and has become an option for obtaining an accurate depth assessment and enabling wound re-epithelialization with less skin graft use. We conducted a prospective study from July 2015 to July 2018, which enrolled patients with deep partial-thickness hand burns and treated them with ED using bromelain. After a specified period, we assessed the patients' hand function, using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and the Michigan Hand Outcomes Questionnaire (MHOQ) to assess their disabilities and activities of daily life, respectively. We assessed the hand joint range of motion using a goniometer and assessed scar quality with the Vancouver Scar Scale (VSS). We analyzed 72 patients with 90 burned hands at 3 months and, at the final assessment, 69 patients with 86 burned hands. Fire was the most common cause of the burns. Bromelain allowed for early debridement (73.6% during the first 24 h). At the 3-month evaluation, the mean DASH and MHOQ scores were 2.35 and 97.9%, respectively, with a high inverse correlation between the 2 types of scores (Spearman's rho, -0.78; p < .001). The mean wrist flexion and extension were 85.7 and 80°, respectively, the mean metacarpophalangeal flexion was 88.3°, the proximal interphalangeal (PIP) flexion was 112.9°, and the thumb opposition was 77°. The mean VSS score was 2.87. At the final evaluation, with a minimum follow-up of 391 days, the mean DASH and MHOQ scores were 0.18 and 99.71%, respectively. ED with bromelain in deep partial-thickness hand burns resulted in normal values at 3 months and at over 1 year of follow-up, with complete restoration of function and quality of life and good scar results.
手部烧伤是常见的损伤,可导致手部功能长期受损。酶清创术 (ED) 可防止由于该程序的选择性而对有活力的真皮造成损害,并且已经成为获得准确深度评估和减少皮肤移植使用以促进伤口再上皮化的一种选择。我们进行了一项前瞻性研究,从 2015 年 7 月至 2018 年 7 月,招募了患有深度部分厚度手部烧伤的患者,并使用菠萝蛋白酶进行 ED 治疗。在特定时间段后,我们使用残疾的手臂、肩部和手 (DASH) 问卷和密歇根手部结果问卷 (MHOQ) 评估患者的手部功能,分别评估残疾和日常生活活动。我们使用量角器评估手部关节活动范围,并使用温哥华瘢痕量表 (VSS) 评估瘢痕质量。我们分析了 72 例 90 只烧伤手的患者,在最终评估时,69 例 86 只烧伤手的患者。烧伤最常见的原因是火灾。菠萝蛋白酶可早期清创 (73.6%在 24 小时内)。在 3 个月评估时,DASH 和 MHOQ 的平均得分分别为 2.35 和 97.9%,两种评分之间呈高度负相关 (Spearman's rho,-0.78;p<0.001)。手腕弯曲和伸展的平均角度分别为 85.7°和 80°,掌指关节弯曲的平均角度为 88.3°,近指间关节 (PIP) 弯曲的平均角度为 112.9°,拇指对掌的平均角度为 77°。平均 VSS 评分为 2.87。在最终评估时,随访时间最短为 391 天,DASH 和 MHOQ 的平均得分分别为 0.18 和 99.71%。菠萝蛋白酶在深度部分厚度手部烧伤中的 ED 治疗可在 3 个月和 1 年以上的随访中达到正常水平,功能和生活质量完全恢复,瘢痕结果良好。