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HIF2α Activation in NASH: A New Force Pushing Toward HCC.

作者信息

Clavería-Cabello Alex, Avila Matías A

机构信息

Hepatology Program, CIMA, University of Navarra, Pamplona, Spain; Maite G. Fernandez-Barrena, Hepatology Program, CIMA, University of Navarra, Pamplona, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigaciones Sanitarias de Navarra IdiSNA, Pamplona, Spain.

Hepatology Program, CIMA, University of Navarra, Pamplona, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigaciones Sanitarias de Navarra IdiSNA, Pamplona, Spain.

出版信息

Cell Mol Gastroenterol Hepatol. 2022;13(2):678-680. doi: 10.1016/j.jcmgh.2021.11.005. Epub 2021 Nov 27.

DOI:10.1016/j.jcmgh.2021.11.005
PMID:34848185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8777000/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8f/8777000/9e895c78fe84/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8f/8777000/9e895c78fe84/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8f/8777000/9e895c78fe84/gr1.jpg

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本文引用的文献

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Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation.肝细胞特异性敲除 HIF2α 通过降低癌细胞增殖预防 NASH 相关肝癌发生。
Cell Mol Gastroenterol Hepatol. 2022;13(2):459-482. doi: 10.1016/j.jcmgh.2021.10.002. Epub 2021 Oct 14.
2
NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options.非酒精性脂肪性肝病相关肝细胞癌：现有和新兴治疗选择的安全性和疗效。
J Hepatol. 2022 Feb;76(2):446-457. doi: 10.1016/j.jhep.2021.09.007. Epub 2021 Sep 20.
3
What Does the Future Hold for Patients With Nonalcoholic Steatohepatitis: Diagnostic Strategies and Treatment Options in 2021 and Beyond?
The STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway.
非酒精性脂肪性肝病中的STING：炎症-致癌途径中的潜在治疗靶点
Pharmaceuticals (Basel). 2022 Oct 9;15(10):1241. doi: 10.3390/ph15101241.
非酒精性脂肪性肝炎患者的未来如何：2021 年及以后的诊断策略和治疗选择？
Hepatol Commun. 2021 Nov;5(11):1810-1823. doi: 10.1002/hep4.1814. Epub 2021 Sep 9.
4
Nonalcoholic steatohepatitis: global impact and clinical consequences.非酒精性脂肪性肝炎：全球影响及临床后果
Endocr Connect. 2021 Oct 7;10(10):R240-R247. doi: 10.1530/EC-21-0048.
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Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis.非酒精性脂肪性肝炎患者肝细胞癌的分子特征。
J Hepatol. 2021 Oct;75(4):865-878. doi: 10.1016/j.jhep.2021.04.049. Epub 2021 May 13.
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NASH limits anti-tumour surveillance in immunotherapy-treated HCC.NASH 限制了免疫治疗治疗 HCC 的肿瘤监测。
Nature. 2021 Apr;592(7854):450-456. doi: 10.1038/s41586-021-03362-0. Epub 2021 Mar 24.
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Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020).缺氧诱导因子 (HIF) 抑制剂：专利调查（2016-2020 年）。
Expert Opin Ther Pat. 2021 May;31(5):387-397. doi: 10.1080/13543776.2021.1874345. Epub 2021 Jan 29.
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Signal Transduct Target Ther. 2020 Jul 10;5(1):124. doi: 10.1038/s41392-020-00235-2.
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Nat Rev Gastroenterol Hepatol. 2019 Jul;16(7):411-428. doi: 10.1038/s41575-019-0145-7.