University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil; Butantan Institute, São Paulo, Brazil.
University of São Paulo, Ribeirão Preto Medical School, Blood Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Virus Res. 2022 Jan 15;308:198643. doi: 10.1016/j.virusres.2021.198643. Epub 2021 Nov 27.
The SARS-CoV-2 alpha VOC (also known as lineage B.1.1.7) initially described in the autumn, 2020 in UK, rapidly became the dominant lineage across much of Europe. Despite multiple studies reporting molecular evidence suggestive of its circulation in Brazil, much is still unknown about its genomic diversity in the state of São Paulo, the main Brazilian economic and transportation hub. To get more insight regarding its transmission dynamics into the State we performed phylogenetic analysis on all alpha VOC strains obtained between February and August 2021 from the Sao Paulo state Network for Pandemic Alert of Emerging SARS-CoV-2 variants. The performed phylogenetic analysis showed that most of the alpha VOC genomes were interspersed with viral strains sampled from different Brazilian states and other countries suggesting that multiple independent Alpha VOC introductions from Brazil and overseas have occurred in the São Paulo State over time. Nevertheless, large monophyletic clusters were also observed especially from the Central-West part of the São Paulo State (the city of Bauru) and the metropolitan region of the São Paulo city. Our results highlight the Alpha VOC molecular epidemiology in the São Paulo state and reinforce the need for continued genomic surveillance strategies for the real-time monitoring of potential emerging SARS-CoV-2 variants during the ever-growing vaccination process.
2020 年秋季在英国首次描述的 SARS-CoV-2 alpha VOC（也称为谱系 B.1.1.7）迅速成为欧洲大部分地区的主要谱系。尽管有多项研究报告称有分子证据表明其在巴西传播，但关于其在巴西主要经济和交通枢纽圣保罗州的基因组多样性仍知之甚少。为了更深入地了解其传入该州的传播动态，我们对 2021 年 2 月至 8 月期间从圣保罗州 SARS-CoV-2 变异体大流行预警网络获得的所有 alpha VOC 菌株进行了系统发育分析。所进行的系统发育分析表明，大多数 alpha VOC 基因组与从不同巴西州和其他国家采样的病毒株混合在一起，表明随着时间的推移，巴西和海外的多个独立 alpha VOC 传入已经发生在圣保罗州。然而，也观察到了大型单系群，特别是在圣保罗州的中-西部（包鲁市）和圣保罗市的大都市区。我们的研究结果突出了圣保罗州的 alpha VOC 分子流行病学，并强调需要继续进行基因组监测策略，以实时监测在不断增长的疫苗接种过程中潜在的新出现的 SARS-CoV-2 变体。
