Pearlson G D, Tune L E
Psychiatry Res. 1986 Jan;17(1):23-9. doi: 10.1016/0165-1781(86)90038-7.
Computed tomography (CT) was performed in 16 patients with a diagnosis of senile dementia of the Alzheimer type (SDAT). CT scans were rated without knowledge of clinical and laboratory data, and lateral ventricle-brain ratios (VBRs) calculated. Cerebrospinal fluid (CSF) acetylcholinesterase (AChE) activity was measured by radioenzymatic assay in all patients, and degree of dementia quantified using the Mini-Mental State Examination (MMSE). There were significant correlations between cerebral atrophy as assessed by VBR and CSF AChE activity. Cognitive impairment on MMSE also correlated significantly with VBR. These correlations were not accounted for by age, dilutional effects, or duration of illness. The relationship between VBR and AChE activity demonstrates an association between two independently determined pre-mortem measures of illness.
对16例诊断为阿尔茨海默型老年痴呆症（SDAT）的患者进行了计算机断层扫描（CT）。在不了解临床和实验室数据的情况下对CT扫描进行评分，并计算侧脑室-脑比率（VBR）。对所有患者通过放射酶法测定脑脊液（CSF）乙酰胆碱酯酶（AChE）活性，并使用简易精神状态检查表（MMSE）对痴呆程度进行量化。通过VBR评估的脑萎缩与CSF AChE活性之间存在显著相关性。MMSE上的认知障碍也与VBR显著相关。这些相关性不受年龄、稀释效应或病程的影响。VBR与AChE活性之间的关系表明了两种独立确定的生前疾病测量指标之间的关联。
