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多发性骨髓瘤患者的环状毛发

Circle Hairs in a Patient with Multiple Myeloma.

作者信息

Limtong Preeyachat, Suchonwanit Poonkiat

机构信息

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Clin Cosmet Investig Dermatol. 2021 Nov 23;14:1767-1772. doi: 10.2147/CCID.S343365. eCollection 2021.

DOI:10.2147/CCID.S343365
PMID:34848987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8627239/
Abstract

Circle hair is a rare body-hair disorder of unknown etiology, typically characterized by perfectly or nearly perfectly coiled hair located below the cornified layer of the skin. Its main histopathological features are dilated hair-follicle infundibula and entrapped hair shafts. After its first description in 1963, there have only been a small number of reported cases, and its pathophysiology remains unclear. Herein, we report a case of an 80-year-old woman with skin lesions and abnormal hairs on both legs. We also propose a possible mechanism of her circle hairs: it may have occurred as an effect of her acquired ichthyosis secondary to her underlying multiple myeloma. There is no specific treatment for circle hairs, and reassurance that it is a harmless condition is sufficient. We prescribed a topical humectant and keratolytic agent to moisten the skin and lessen the hair entrapment, which resulted in clinical improvement. As the pathogenesis of the disease is unknown, further studies are warranted.

摘要

环形毛发是一种病因不明的罕见体毛疾病,其典型特征是位于皮肤角质层下方的毛发完美或近乎完美地盘绕。其主要组织病理学特征是毛囊漏斗扩张和毛发干被困。自1963年首次描述以来,仅有少数病例报道,其病理生理学仍不清楚。在此,我们报告一例80岁女性双下肢皮肤病变和毛发异常的病例。我们还提出了她环形毛发的一种可能机制:可能是由于其潜在的多发性骨髓瘤继发获得性鱼鳞病所致。环形毛发没有特效治疗方法,告知患者这是一种无害状况就足够了。我们开了一种外用保湿剂和角质溶解剂来滋润皮肤并减少毛发被困,临床症状得到改善。由于该疾病的发病机制尚不清楚,有必要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/26311353b586/CCID-14-1767-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/46ad9ece22e7/CCID-14-1767-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/9f6c31431705/CCID-14-1767-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/26311353b586/CCID-14-1767-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/46ad9ece22e7/CCID-14-1767-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/9f6c31431705/CCID-14-1767-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e5/8627239/26311353b586/CCID-14-1767-g0003.jpg

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1
Circle Hairs in a Patient with Multiple Myeloma.多发性骨髓瘤患者的环状毛发
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Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin-based cornification during hair evolution.单孔目动物毛发的精细结构与免疫细胞化学,重点关注毛发进化过程中的内根鞘和基于毛透明蛋白的角质化。
J Morphol. 2004 Sep;261(3):345-63. doi: 10.1002/jmor.10254.
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Circle hairs: clinical, trichoscopic and histopathologic findings.环状毛发:临床、毛发镜及组织病理学表现
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Porokeratotic eccrine duct and hair follicle nevus (PEHFN) associated with keratitis-ichthyosis-deafness (KID) syndrome.伴有角膜炎-鱼鳞病-耳聋(KID)综合征的汗管和毛囊角化性痣(PEHFN)
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本文引用的文献

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Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata.斑秃患者自身免疫性疾病发生的患病率及相关危险因素。
J Inflamm Res. 2021 Sep 22;14:4881-4891. doi: 10.2147/JIR.S331579. eCollection 2021.
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A clinical and histological comparison between acute cutaneous graft-versus-host disease and other maculopapular eruptions following hematopoietic stem cell transplantation: a retrospective cohort.急性皮肤移植物抗宿主病与造血干细胞移植后其他斑丘疹性发疹的临床和组织学比较:一项回顾性队列研究。
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Asian Hair: A Review of Structures, Properties, and Distinctive Disorders.
亚洲人头发:结构、特性及特殊病症综述
Clin Cosmet Investig Dermatol. 2020 Apr 24;13:309-318. doi: 10.2147/CCID.S247390. eCollection 2020.
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Circle hairs in a cardiac transplant patient.
J Eur Acad Dermatol Venereol. 2020 Sep;34(9):e472-e474. doi: 10.1111/jdv.16381. Epub 2020 May 8.
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Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date.非那雄胺及其治疗女性型脱发的潜力:现有证据。
Drug Des Devel Ther. 2020 Mar 2;14:951-959. doi: 10.2147/DDDT.S240615. eCollection 2020.
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Nonscarring alopecia in systemic lupus erythematosus: A cross-sectional study with trichoscopic, histopathologic, and immunopathologic analyses.系统性红斑狼疮中的非瘢痕性脱发:一项横断面研究,结合了毛发镜、组织病理学和免疫病理学分析。
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A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia.一项 1550nm 分段式铒玻璃激光联合外用 5%米诺地尔与单独使用 5%米诺地尔治疗雄激素性脱发的随机、研究者设盲、对照、分头皮研究
Lasers Med Sci. 2019 Dec;34(9):1857-1864. doi: 10.1007/s10103-019-02783-8. Epub 2019 Apr 13.
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Trichoscopic signs in systemic lupus erythematosus: a comparative study with 109 patients and 305 healthy controls.系统性红斑狼疮的毛发镜检查特征:109 例患者与 305 例健康对照者的对比研究。
J Eur Acad Dermatol Venereol. 2019 Apr;33(4):774-780. doi: 10.1111/jdv.15421. Epub 2019 Feb 18.
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Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study.0.25%非那雄胺和 3%米诺地尔联合外用治疗女性型脱发的疗效:一项随机、双盲、对照研究。
Am J Clin Dermatol. 2019 Feb;20(1):147-153. doi: 10.1007/s40257-018-0387-0.
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Alopecia in Association with Malignancy: A Review.与恶性肿瘤相关的脱发:综述。
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