红细胞分布宽度：一种对多种疾病的诊断和治疗具有预测价值的新型指标。
ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases.
作者信息
Wang Jingsheng, Xiao Qiang, Li Yuanmin
机构信息
Department of Cardiology, the Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People's Republic of China.
出版信息
Int J Gen Med. 2021 Nov 23;14:8667-8675. doi: 10.2147/IJGM.S339945. eCollection 2021.
Abstract
Elevated red blood cell distribution width (RDW) is a powerful predictor of poor prognosis in a variety of diseases, but a single measurement of RDW cannot reflect the dynamic change of diseases. ΔRDW, as a risk stratification tool, can be used to record changes in RDW before and after treatment; also, it allows investigators to name the unit change of RDW in the studied population. So far, there have been few relevant studies on the predictive value of ΔRDW for different diseases; this article aims to review the studies and summaries of the current understandings on the correlation between ΔRDW and disease outcomes.
摘要
红细胞分布宽度（RDW）升高是多种疾病预后不良的有力预测指标，但单次测量RDW无法反映疾病的动态变化。ΔRDW作为一种风险分层工具，可用于记录治疗前后RDW的变化；此外，它还能让研究人员确定所研究人群中RDW的单位变化。到目前为止，关于ΔRDW对不同疾病预测价值的相关研究较少；本文旨在回顾相关研究，并总结目前对ΔRDW与疾病预后之间相关性的认识。
相似文献
1
ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases.红细胞分布宽度：一种对多种疾病的诊断和治疗具有预测价值的新型指标。
Int J Gen Med. 2021 Nov 23;14:8667-8675. doi: 10.2147/IJGM.S339945. eCollection 2021.
2
Both initial red cell distribution width (RDW) and change in RDW during heart failure hospitalization are associated with length of hospital stay and 30-day outcomes.初始红细胞分布宽度（RDW）以及心力衰竭住院期间RDW的变化均与住院时间和30天预后相关。
Int J Lab Hematol. 2016 Jun;38(3):328-37. doi: 10.1111/ijlh.12490.
3
Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection.动态增加的红细胞分布宽度对极低出生体重儿严重细菌感染的诊断准确性。
Ital J Pediatr. 2021 Feb 27;47(1):44. doi: 10.1186/s13052-021-00994-w.
4
Relation between changes in red blood cell distribution width after coronary artery bypass grafting and early postoperative morbidity.冠状动脉旁路移植术后红细胞分布宽度变化与术后早期发病率的关系
J Thorac Dis. 2018 Jul;10(7):4244-4254. doi: 10.21037/jtd.2018.06.108.
5
Prognostic significance of changes in red cell distribution width in an internal medicine ward.内科病房红细胞分布宽度变化的预后意义。
Eur J Intern Med. 2015 Oct;26(8):616-22. doi: 10.1016/j.ejim.2015.07.018. Epub 2015 Aug 6.
6
Enlarging Red Blood Cell Distribution Width During Hospitalization Identifies a Very High-Risk Subset of Acutely Decompensated Heart Failure Patients and Adds Valuable Prognostic Information on Top of Hemoconcentration.住院期间红细胞分布宽度增大可识别急性失代偿性心力衰竭患者的极高风险亚组，并在血液浓缩基础上增加有价值的预后信息。
Medicine (Baltimore). 2016 Apr;95(14):e3307. doi: 10.1097/MD.0000000000003307.
7
The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study.输血对危重症患者红细胞分布宽度的影响：一项初步研究。
Transfusion. 2018 Aug;58(8):1863-1869. doi: 10.1111/trf.14759. Epub 2018 May 16.
8
Effect of purified eicosapentaenoic acid on red cell distribution width in patients with ischemic heart disease.纯化的二十碳五烯酸对缺血性心脏病患者红细胞分布宽度的影响。
Heart Vessels. 2015 Sep;30(5):587-94. doi: 10.1007/s00380-014-0526-3. Epub 2014 May 31.
9
Red cell distribution width is associated with cardiovascular risk and disease parameters in rheumatoid arthritis.红细胞分布宽度与类风湿关节炎的心血管风险及疾病参数相关。
Rheumatology (Oxford). 2015 Apr;54(4):641-6. doi: 10.1093/rheumatology/keu345. Epub 2014 Sep 18.
10
Early in-hospital variation of red blood cell distribution width predicts mortality in patients with acute heart failure.红细胞分布宽度的早期院内变化可预测急性心力衰竭患者的死亡率。
Int J Cardiol. 2017 Sep 15;243:306-310. doi: 10.1016/j.ijcard.2017.05.023. Epub 2017 May 6.
引用本文的文献
1
Prognostic value of hemoglobin-to-red cell distribution width ratio in patients with thoracoabdominal aortic aneurysm: a MIMIC-IV database-based retrospective study.血红蛋白与红细胞分布宽度比值在胸腹主动脉瘤患者中的预后价值：一项基于MIMIC-IV数据库的回顾性研究
J Thorac Dis. 2025 Aug 31;17(8):6004-6016. doi: 10.21037/jtd-2025-72. Epub 2025 Aug 28.
2
Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients.贫血对急性心力衰竭患者红细胞分布宽度与1年死亡率之间关联的影响。
Ther Adv Cardiovasc Dis. 2025 Jan-Dec;19:17539447251366798. doi: 10.1177/17539447251366798. Epub 2025 Aug 22.
3
Association of Red Blood Cell Distribution Width With Carotid-Femoral Pulse Wave Velocity in a Southern Chinese Population.中国南方人群中红细胞分布宽度与颈股动脉脉搏波速度的关联
J Clin Hypertens (Greenwich). 2025 Jan;27(1):e14964. doi: 10.1111/jch.14964.
4
Association between red blood cell distribution width and all-cause mortality of patients after intra-aortic balloon pump in the intensive care unit.重症监护病房中主动脉内球囊反搏术后患者红细胞分布宽度与全因死亡率的相关性
Heliyon. 2024 Mar 10;10(6):e27498. doi: 10.1016/j.heliyon.2024.e27498. eCollection 2024 Mar 30.
5
Prognostic significance of increased preoperative red cell distribution width (RDW) and changes in RDW for colorectal cancer.术前红细胞分布宽度（RDW）升高及 RDW 变化对结直肠癌的预后意义。
Cancer Med. 2023 Jun;12(12):13361-13373. doi: 10.1002/cam4.6036. Epub 2023 May 4.
6
Red Cell Distribution Width as a Predictive Factor of Celiac Disease in Middle and Late Adulthood and Its Potential Utility as Celiac Disease Screening Criterion.红细胞分布宽度作为中晚期成人乳糜泻的预测因子及其作为乳糜泻筛查标准的潜在应用。
Int J Environ Res Public Health. 2022 Dec 21;20(1):66. doi: 10.3390/ijerph20010066.
7
Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall.红细胞分布宽度与血细胞与血管壁的相互作用增加有关。
Sci Rep. 2022 Aug 11;12(1):13676. doi: 10.1038/s41598-022-17847-z.
8
Dynamic Changes in Red Cell Distribution Width Can Predict Major Adverse Cardiovascular Events after PCI in Patients with Unstable Angina Pectoris: A Retrospective Cohort Study.红细胞分布宽度的动态变化可预测不稳定型心绞痛患者 PCI 后主要不良心血管事件：一项回顾性队列研究。
Dis Markers. 2022 Jun 8;2022:2735717. doi: 10.1155/2022/2735717. eCollection 2022.
本文引用的文献
1
Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study.红细胞分布宽度与糖尿病视网膜病变的关联：一项5年回顾性病例对照研究。
J Ophthalmol. 2021 Jul 6;2021:6653969. doi: 10.1155/2021/6653969. eCollection 2021.
2
Correlation of the changing trends of red cell distribution width and serum lactate as a prognostic factor in sepsis and septic shock.红细胞分布宽度与血清乳酸变化趋势作为脓毒症和脓毒性休克预后因素的相关性
J Anaesthesiol Clin Pharmacol. 2020 Oct-Dec;36(4):531-534. doi: 10.4103/joacp.JOACP_105_19. Epub 2021 Jan 18.
3
Red Cell Distribution Width, Anemia, and Brain Volumetric Outcomes Among Middle-Aged Adults.红细胞分布宽度、贫血与中年人群的脑容量变化
J Alzheimers Dis. 2021;81(2):711-727. doi: 10.3233/JAD-201386.
4
Dynamic Increase of Red Cell Distribution Width Predicts Increased Risk of 30-Day Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.红细胞分布宽度的动态增加预示着慢性阻塞性肺疾病急性加重患者 30 天再入院风险增加。
Int J Chron Obstruct Pulmon Dis. 2021 Feb 24;16:393-400. doi: 10.2147/COPD.S291833. eCollection 2021.
5
Fluctuation in red cell distribution width predicts disseminated intravascular coagulation morbidity and mortality in sepsis: a retrospective single-center study.红细胞分布宽度波动预测脓毒症弥散性血管内凝血发病率和死亡率：一项回顾性单中心研究。
Minerva Anestesiol. 2021 Jan;87(1):52-64. doi: 10.23736/S0375-9393.20.14420-1.
6
Correlations of disease severity and age with hematology parameter variations in patients with COVID-19 pre- and post-treatment.COVID-19患者治疗前后疾病严重程度和年龄与血液学参数变化的相关性。
J Clin Lab Anal. 2021 Jan;35(1):e23609. doi: 10.1002/jcla.23609. Epub 2020 Nov 21.
7
Association between red blood cell distribution width and mortality of COVID-19 patients.红细胞分布宽度与 COVID-19 患者死亡率的关系。
Anaesth Crit Care Pain Med. 2021 Feb;40(1):100777. doi: 10.1016/j.accpm.2020.10.013. Epub 2020 Nov 7.
8
Anisocytosis is Associated With Short-Term Mortality in COVID-19 and May Reflect Proinflammatory Signature in Uninfected Ambulatory Adults.红细胞大小不均与新冠肺炎的短期死亡率相关，且可能反映未感染的非卧床成年人的促炎特征。
Pathog Immun. 2020 Oct 2;5(1):312-326. doi: 10.20411/pai.v5i1.391. eCollection 2020.
9
Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection.红细胞分布宽度与住院成人 SARS-CoV-2 感染患者死亡风险的关联。
JAMA Netw Open. 2020 Sep 1;3(9):e2022058. doi: 10.1001/jamanetworkopen.2020.22058.
10
Red Blood Cell Distribution Width (RDW) Predicts COVID-19 Severity: A Prospective, Observational Study from the Cincinnati SARS-CoV-2 Emergency Department Cohort.红细胞分布宽度（RDW）可预测新冠病毒疾病（COVID-19）的严重程度：一项来自辛辛那提SARS-CoV-2急诊科队列的前瞻性观察研究。
Diagnostics (Basel). 2020 Aug 21;10(9):618. doi: 10.3390/diagnostics10090618.
Zotero 插件