贫血对急性心力衰竭患者红细胞分布宽度与1年死亡率之间关联的影响。

Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients.

作者信息

Maita-Arauco Sherelym Alessandra, Quispe-Vasquez Sthephanie María, Benites-Zapata Vicente Aleixandre, Segura-Saldaña Pedro Antonio

机构信息

Universidad Peruana de Ciencias Aplicadas, Escuela de Medicina, Lima, Peru.

Universidad San Ignacio de Loyola, Unidad para la Generación y Síntesis de Evidencias en Salud, Avenida La Fontana #750, La Molina, Lima 15024, Peru.

出版信息

Ther Adv Cardiovasc Dis. 2025 Jan-Dec;19:17539447251366798. doi: 10.1177/17539447251366798. Epub 2025 Aug 22.

DOI:10.1177/17539447251366798

PMID:40844908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12374119/

Abstract

BACKGROUND

Different accessible and low-cost biomarkers have been investigated to stratify patients with acute heart failure (AHF). One of them is the red cell distribution width (RDW), which proved to be a greater prognostic marker of mortality than other conventional markers.

OBJECTIVE

Therefore, the objective of our study is to determine whether the anemic status modifies the magnitude of association between high RDW and 1-year mortality in patients with AHF.

DESIGN

Observational, analytical, retrospective cohort study.

METHODS

We included participants ⩾18 years old hospitalized with a diagnosis of AHF. As an association measure, a crude and adjusted generalized linear model of the Poisson family calculated the risk ratio (RR) with a 95% confidence interval (95% CI).

RESULTS

In all, 709 participants with an average age of 73.48 years were included. At 1 year, the risk of dying was three times higher with high RDW (RR = 3.05, 95% CI: 1.39-6.66; < 0.01). In anemic participants, the risk of dying at 1 year is two times greater with high RDW (RR = 2.18, 95% CI: 0.91-5.22; = 0.07), while in non-anemic participants, the risk of dying increased almost seven times (RR = 6.95, 95% CI: 1.65-29.23; < 0.01).

CONCLUSION

High RDW is a risk factor for mortality at 1 year in patients with AHF. A greater magnitude of association was found in non-anemic patients.

摘要

背景

人们已经研究了不同的可获取且低成本的生物标志物，用于对急性心力衰竭（AHF）患者进行分层。其中之一是红细胞分布宽度（RDW），事实证明它是比其他传统标志物更强的死亡预后指标。

目的

因此，我们研究的目的是确定贫血状态是否会改变AHF患者中高RDW与1年死亡率之间关联的程度。

设计

观察性、分析性、回顾性队列研究。

方法

我们纳入了年龄≥18岁、因AHF诊断而住院的参与者。作为关联指标，采用泊松族的粗算和校正广义线性模型计算风险比（RR）及95%置信区间（95%CI）。

结果

总共纳入了709名平均年龄为73.48岁的参与者。1年时，高RDW者的死亡风险高出三倍（RR = 3.05，95%CI：1.39 - 6.66；P < 0.01）。在贫血参与者中，高RDW者1年时的死亡风险高出两倍（RR = 2.18，95%CI：0.91 - 5.22；P = 0.07），而在非贫血参与者中，死亡风险增加了近七倍（RR = 6.95，95%CI：1.65 - 29.23；P < 0.01）。