Achdiat Pati Aji, Adriyani Kristina Makarti, Pospos Argani Gracias, Rowawi Rasmia, Hindritiani Reti, Suwarsa Oki, Gunawan Hendra
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
HIV AIDS (Auckl). 2021 Nov 20;13:993-997. doi: 10.2147/HIV.S341856. eCollection 2021.
Molluscum contagiosum (MC) is an infectious disease caused by the MC virus. In human immunodeficiency virus (HIV) patients, MC has an atypical predilection and prominence, sometimes measuring more than 1 cm in diameter, known as giant MC. Giant MC lesions on the eyelids are rare. There is no standardized therapy for eyelids MC in HIV patients. Antiretroviral (ARV) administration is recommended as the primary treatment for MC in HIV patients along with other treatment modalities, such as potassium hydroxide (KOH). The 20% KOH solution is a keratolytic agent with good efficacy as MC therapy. Two cases of giant MC on the eyelids of stage 2 HIV patients with respective CD4+ of 31 cells/μL and 46 cells/μL were reported. The lesions consisted of multiple confluent papules with central umbilication, and Tzanck smear revealed Henderson-Patterson bodies. Both patients were treated with ARV and self-applied 20% KOH solution once daily. The lesions improved after four weeks of therapy in both patients with most of the lesions diminished. The successful treatment with 20% KOH solution for giant MC on the eyelids of HIV patients observed in the current study provides evidence that treatment with this solution yielded prompt results, is non-toxic, and can be self-applied.
传染性软疣（MC）是由MC病毒引起的一种传染病。在人类免疫缺陷病毒（HIV）患者中，MC具有非典型的偏好和突出表现，有时直径超过1厘米，称为巨大型MC。眼睑上的巨大型MC病变罕见。HIV患者眼睑MC没有标准化的治疗方法。抗逆转录病毒（ARV）治疗被推荐作为HIV患者MC的主要治疗方法，同时结合其他治疗方式，如氢氧化钾（KOH）。20%的KOH溶液是一种角质溶解剂，作为MC治疗药物疗效良好。报告了2例2期HIV患者眼睑巨大型MC病例，其CD4 + 细胞计数分别为31个/μL和46个/μL。病变由多个融合的丘疹组成，中央有脐凹，Tzanck涂片显示亨德森 - 帕特森小体。两名患者均接受ARV治疗，并每天自行涂抹一次20%的KOH溶液。治疗四周后，两名患者的病变均有改善，大多数病变缩小。本研究中观察到的用20% KOH溶液成功治疗HIV患者眼睑巨大型MC的案例证明，该溶液治疗效果迅速、无毒且可自行使用。
