Kupczyk Daria, Bilski Rafał, Przewięźlikowski Andrzej, Studziñska Renata, Woźniak Alina
Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Private Nursing Practice Andrzej Przewiêźlikowski, Torun, Poland.
Postepy Dermatol Alergol. 2021 Oct;38(5):767-772. doi: 10.5114/ada.2020.96702. Epub 2020 Aug 18.
Difficult healing of chronic wounds is a serious problem for modern medicine. It leads to ulceration, especially in conditions such as diabetic foot syndrome or chronic venous insufficiency. This may be a result of chemical, physical, thermal or biological factors, among others. Analysis of mediators and molecular factors released by the abovementioned structure helps to better understand the mechanism of healing of chronic wounds and the formation of ulcers.
To assess excretion of selected cytokines in patients with ulcerations as a complication of diabetes mellitus type 2.
Seventeen patients aged 68-87 took part in the assessment of wound healing in patients with ulceration in the course of diabetes mellitus type 2. The control group consisted of 21 healthy patients aged 32-62. In the blood serum bFGF, TNF-α, IL-4, TGF-β1, TGF-β2 and TGF-β3 were determined.
A significant difference was found in bFGF, IL-4, TGF-β1, TGF-β2, and TGF-β3 levels. Concentration of bFGF was 12% lower in patients with ulcers than in the non-ulcerated control group ( = 0.013). IL-4 concentration was 46% lower in patients with ulcers than in the non-ulcerated control group ( = 0.002). TGF-β1, TGF-β2 and TGF-β3 concentrations were also lower in the group of patients with ulcers compared to those in the non-ulcerated control group.
Reduced concentrations of selected cytokines and growth factors may indicate abnormal activity of the cells that secrete them and affect the healing process of chronic wounds, hindering and delaying the healing process.
慢性伤口愈合困难是现代医学面临的一个严重问题。它会导致溃疡，尤其是在糖尿病足综合征或慢性静脉功能不全等情况下。这可能是由化学、物理、热或生物等多种因素导致的。对上述结构释放的介质和分子因子进行分析，有助于更好地理解慢性伤口愈合机制以及溃疡的形成。
评估2型糖尿病并发症溃疡患者中所选细胞因子的排泄情况。
17名年龄在68 - 87岁的患者参与了2型糖尿病病程中溃疡患者伤口愈合情况的评估。对照组由21名年龄在32 - 62岁的健康患者组成。测定血清中的碱性成纤维细胞生长因子（bFGF）、肿瘤坏死因子-α（TNF-α）、白细胞介素-4（IL-4）、转化生长因子-β1（TGF-β1）、转化生长因子-β2（TGF-β2）和转化生长因子-β3（TGF-β3）。
发现bFGF、IL-4、TGF-β1、TGF-β2和TGF-β3水平存在显著差异。溃疡患者的bFGF浓度比未患溃疡的对照组低12%（P = 0.013）。溃疡患者的IL-4浓度比未患溃疡的对照组低46%（P = 0.002）。与未患溃疡的对照组相比，溃疡患者组的TGF-β1、TGF-β2和TGF-β3浓度也较低。
所选细胞因子和生长因子浓度降低可能表明分泌它们的细胞活性异常，并影响慢性伤口的愈合过程，阻碍和延迟愈合进程。
