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六和丹对兔皮肤感染性伤口愈合过程中IL-1和bFGF表达影响的实验研究

Experimental Study on the Expression of IL-1 and bFGF in Wound Healing Process of Rabbit Cutaneous Infective Wound in Liu-He-Dan.

作者信息

Lv Changyao, Wu Jing, He Hongbo

机构信息

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:7230178. doi: 10.1155/2017/7230178. Epub 2017 Dec 10.

DOI:10.1155/2017/7230178
PMID:29375643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5742465/
Abstract

OBJECTIVE

This study applied Liu-He-Dan (LHD) to treat the infective wounds of rabbits to explore the mechanism of LHD in promoting wound healing.

METHOD

Five circular infective incisions were generated on the back of each rabbit. Wound dressings were performed every day since postoperative day 1. Ten rabbits were euthanized on days 3, 7, 14, and 21. Each specimen was divided into two parts, one was used for detecting interleukin-1 beta (IL-1), and the other one was used for detecting basic fibroblast growth factor (bFGF).

RESULT

The content of IL-1 in the model group was higher than those in the other groups ( < 0.05). The content of IL-1 in the treatment group was lower than the other groups on days 14 and 21. The expression of bFGF in treatment group is significant on days 3, 7, and 14, compared with traditional Chinese medicine group and model group. The expression of bFGF has no significant difference with Western group.

CONCLUSION

The research approved that LHD could specifically suppress the expression of IL-1 and upregulate the expression of bFGF in the wound, decreasing the release of inflammatory factor of the infective wounds and promoting the healing of the infective wounds.

摘要

目的

本研究应用六合丹（LHD）治疗兔感染性伤口，探讨LHD促进伤口愈合的机制。

方法

在每只兔背部制作5个圆形感染切口。自术后第1天起每天进行伤口换药。分别于术后第3、7、14和21天对10只兔实施安乐死。每个标本分成两部分，一部分用于检测白细胞介素-1β（IL-1），另一部分用于检测碱性成纤维细胞生长因子（bFGF）。

结果

模型组IL-1含量高于其他组（<0.05）。治疗组在第14天和21天时IL-1含量低于其他组。与中药组和模型组相比，治疗组在第3、7和14天时bFGF表达显著。bFGF表达与西药组无显著差异。

结论

本研究证实LHD可特异性抑制伤口中IL-1的表达并上调bFGF的表达，减少感染性伤口炎症因子的释放，促进感染性伤口的愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/aab507feb47b/ECAM2017-7230178.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/786cd21a7592/ECAM2017-7230178.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/fe3f735406d6/ECAM2017-7230178.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/3ecceea0dbcb/ECAM2017-7230178.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/cf6b0bd14ff7/ECAM2017-7230178.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/aab507feb47b/ECAM2017-7230178.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/786cd21a7592/ECAM2017-7230178.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/fe3f735406d6/ECAM2017-7230178.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/3ecceea0dbcb/ECAM2017-7230178.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/cf6b0bd14ff7/ECAM2017-7230178.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969b/5742465/aab507feb47b/ECAM2017-7230178.005.jpg

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