Wang Hong, Shen Guimei, Liu Mengsi, Mao Linjuan, Mao Hui
Department of Obstetrics and Reproductive Center, The Affiliated Hospital of Yunnan University, Kunming, Yunnan 650000, P.R. China.
Exp Ther Med. 2022 Jan;23(1):41. doi: 10.3892/etm.2021.10963. Epub 2021 Nov 12.
Preeclampsia is a common syndrome in pregnancy and a leading cause of mortality of pregnant females and their infants. To investigate the diagnostic and prognostic utility of lncRNA T-cell leukemia/lymphoma 6 (TCL6) in patients with preeclampsia, 120 singleton pregnant females with preeclampsia and another 100 healthy pregnant control subjects were analyzed in the present study. The expression of lncRNA TCL6 in the serum of the included patients was detected. Receiver operating characteristic curve analysis was applied to evaluate the efficiency of lncRNA TCL6 in terms of preeclampsia diagnosis and grading. Kaplan-Meier analysis was adopted to assess the effect of lncRNA TCL6 expression on the rate of adverse pregnancy. Multivariate logistic regression was used to determine high-risk factors of adverse pregnancy. The results indicated that lncRNA TCL6 was significantly increased in the serum of patients with preeclampsia. Furthermore, TCL6 was elevated in subgroups of patients with early-onset or severe preeclampsia and with Haemolysis, Elevated Liver enzymes and Low Platelet count syndrome in comparison with other patients with preeclampsia. High expression of TCL6 in pregnant females corresponded to a higher rate of adverse pregnancy outcomes. Severe preeclampsia, early-onset preeclampsia and high TCL6 expression were identified as independent risk factors for adverse pregnancy outcomes. For each unit increase in TCL6 expression, a 9.5-fold increase of the risk of adverse maternal and fetal outcomes was determined. Collectively, high expression of lncRNA TCL6 may assist the diagnosis and grading of preeclampsia and may be adopted as an independent risk factor for adverse pregnancy outcomes.
子痫前期是妊娠常见综合征，也是孕产女性及其婴儿死亡的主要原因。为研究长链非编码RNA T细胞白血病/淋巴瘤6（TCL6）在子痫前期患者中的诊断及预后价值，本研究分析了120例子痫前期单胎妊娠女性及另外100例健康妊娠对照者。检测纳入患者血清中长链非编码RNA TCL6的表达。采用受试者工作特征曲线分析评估长链非编码RNA TCL6在子痫前期诊断及分级方面的效能。采用Kaplan-Meier分析评估长链非编码RNA TCL6表达对不良妊娠发生率的影响。采用多因素logistic回归确定不良妊娠的高危因素。结果表明，子痫前期患者血清中长链非编码RNA TCL6显著升高。此外，与其他子痫前期患者相比，早发型或重度子痫前期患者及合并溶血、肝酶升高和血小板减少综合征患者的TCL6升高。孕妇TCL6高表达与不良妊娠结局发生率较高相关。重度子痫前期、早发型子痫前期及TCL6高表达被确定为不良妊娠结局的独立危险因素。TCL6表达每增加一个单位，母婴不良结局风险增加9.5倍。总体而言，长链非编码RNA TCL6高表达可能有助于子痫前期的诊断及分级，且可作为不良妊娠结局的独立危险因素。
