Sibira Rayan M, Albakar Ahmed, Younes Nagy, Albozom Issam A, Al Rumaihi Khalid
Department of Laboratory Medicine and Pathology Hamad Medical Corporation Doha Qatar.
Urology Department Hamad Medical Corporation Doha Qatar.
Clin Case Rep. 2021 Nov 22;9(11):e05140. doi: 10.1002/ccr3.5140. eCollection 2021 Nov.
Amyloidosis is related to the extracellular deposition of abnormal protein fibrils in various tissues. It can be either localized to an organ or generalized, affecting multiple systems. Amyloidosis of the urinary bladder is a rare histopathological finding. It is clinically interesting that such cases' clinical, radiological, and even endoscopic presentation mimic urothelial carcinoma to a great extent. Here, we discuss a case of a 49-year-old gentleman who presented with frank painless hematuria. The patient was diagnosed with a bladder mass suspicious of malignancy depending on the clinical presentation aided by the cystoscopic and radiological evaluation. Histopathologic samples of the transurethral resection of the mass proved to be primary bladder amyloidosis. This case is of unique clinical interest in that it is the first case reported of bladder amyloidosis that is complicated by extraperitoneal bladder rupture post-operatively. However, no immediate intraoperative perforation to the bladder wall during resection was evidenced.
淀粉样变性与异常蛋白原纤维在各种组织中的细胞外沉积有关。它可以局限于一个器官，也可以是全身性的，影响多个系统。膀胱淀粉样变性是一种罕见的组织病理学发现。临床上有趣的是，此类病例的临床、放射学甚至内镜表现很大程度上类似于尿路上皮癌。在此，我们讨论一例49岁男性患者，他表现为无痛性肉眼血尿。根据临床表现，借助膀胱镜检查和放射学评估，该患者被诊断为疑似恶性的膀胱肿块。经尿道切除肿块的组织病理学样本证实为原发性膀胱淀粉样变性。该病例具有独特的临床意义，因为它是首例报道的膀胱淀粉样变性术后并发膀胱腹膜外破裂的病例。然而，切除过程中未发现术中立即出现膀胱壁穿孔。
