感染 SARS-CoV-2 的 6 月龄以下婴儿呼吸道病毒载量最高。
Infants Younger Than 6 Months Infected With SARS-CoV-2 Show the Highest Respiratory Viral Loads.
机构信息
Universidad de Buenos Aires-Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
出版信息
J Infect Dis. 2022 Feb 1;225(3):392-395. doi: 10.1093/infdis/jiab577.
Abstract
There is a paucity of reports on the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in infants, because most studies have grouped infants with older children. We analyzed the viral loads of 45318 SARS-CoV-2-positive nasopharyngeal swab samples obtained in Buenos Aires, Argentina. Infants younger than 6 months presented higher viral loads than any other age group. Children older than 6 months showed significantly lower viral loads, similar to those founds in adults. This observation raises new questions regarding the role of infants in the spreading of SARS-CoV-2 infection.
摘要
关于婴儿严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染的特征，报告较少，因为大多数研究将婴儿与年龄较大的儿童归为一组。我们分析了在阿根廷布宜诺斯艾利斯采集的 45318 份 SARS-CoV-2 阳性鼻咽拭子样本的病毒载量。6 个月以下的婴儿比任何其他年龄组的病毒载量都高。6 个月以上的儿童的病毒载量明显较低，与成人相似。这一观察结果提出了有关婴儿在 SARS-CoV-2 感染传播中所起作用的新问题。
相似文献
1
Infants Younger Than 6 Months Infected With SARS-CoV-2 Show the Highest Respiratory Viral Loads.
J Infect Dis. 2022 Feb 1;225(3):392-395. doi: 10.1093/infdis/jiab577.
2
Upper respiratory tract SARS-CoV-2 RNA loads in symptomatic and asymptomatic children and adults.
Clin Microbiol Infect. 2021 Dec;27(12):1858.e1-1858.e7. doi: 10.1016/j.cmi.2021.08.001. Epub 2021 Aug 9.
3
Clinical performance and sample freeze-thaw stability of the cobas®6800 SARS-CoV-2 assay for the detection of SARS-CoV-2 in oro-/nasopharyngeal swabs and lower respiratory specimens.
J Clin Virol. 2020 Dec;133:104686. doi: 10.1016/j.jcv.2020.104686. Epub 2020 Nov 8.
4
Efficient Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from Exhaled Breath.
J Mol Diagn. 2021 Dec;23(12):1661-1670. doi: 10.1016/j.jmoldx.2021.09.005. Epub 2021 Sep 29.
5
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19).
Clin Infect Dis. 2021 Jul 1;73(1):148-150. doi: 10.1093/cid/ciaa1157.
6
Quantitative detection of SARS-CoV-2 RNA in nasopharyngeal samples from infected patients with mild disease.
J Med Virol. 2021 Apr;93(4):2439-2445. doi: 10.1002/jmv.26761. Epub 2021 Jan 5.
7
Symptomatic Infants Have Higher Nasopharyngeal SARS-CoV-2 Viral Loads but Less Severe Disease Than Older Children.
Clin Infect Dis. 2020 Nov 19;71(16):2305-2306. doi: 10.1093/cid/ciaa608.
8
SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19.
Elife. 2021 Aug 20;10:e70458. doi: 10.7554/eLife.70458.
9
Comment on " Infants Younger Than 6 Months Infected With SARS-CoV-2 Show the Highest Respiratory Viral Loads".
J Infect Dis. 2022 Aug 12;226(1):188. doi: 10.1093/infdis/jiac080.
10
Characteristics of Patients Co-infected with Severe Acute Respiratory Syndrome Coronavirus 2 and Dengue Virus, Buenos Aires, Argentina, March-June 2020.
Emerg Infect Dis. 2021 Feb;27(2):348-351. doi: 10.3201/eid2702.203439.
引用本文的文献
1
SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021-2022.
Emerg Infect Dis. 2024 Jun;30(6):1182-1192. doi: 10.3201/eid3006.231427.
2
Clinical and humoral immune response characterization of SARS-CoV-2 Omicron BA.2.38 infection in pediatric patients.
Heliyon. 2023 Jul 11;9(7):e18093. doi: 10.1016/j.heliyon.2023.e18093. eCollection 2023 Jul.
3
Epidemiology and SARS-CoV-2 Infection Patterns among Youth Followed at a Large Los Angeles Health Network during 2020-2022: Clinical Presentation, Prevalent Strains, and Correlates of Disease Severity.
Vaccines (Basel). 2023 May 25;11(6):1024. doi: 10.3390/vaccines11061024.
4
The effect of activity and face masks on exhaled particles in children.
Pediatr Investig. 2023 May 3;7(2):75-85. doi: 10.1002/ped4.12376. eCollection 2023 Jun.
5
COVID-19 in immunocompromised children: comparison of SARS-CoV-2 viral load dynamics between the first and third waves.
Braz J Microbiol. 2023 Sep;54(3):1859-1864. doi: 10.1007/s42770-023-01009-y. Epub 2023 Jun 1.
6
Trends in SARS-CoV-2 cycle threshold values in the Czech Republic from April 2020 to April 2022.
Sci Rep. 2023 Apr 15;13(1):6156. doi: 10.1038/s41598-023-32953-2.
7
Molecular Determinants of the Early Life Immune Response to COVID-19 Infection and Immunization.
Vaccines (Basel). 2023 Feb 22;11(3):509. doi: 10.3390/vaccines11030509.
8
SARS-CoV-2 infections in infants in Haiti 2020-2021; evidence from a seroepidemiological cohort.
PLoS One. 2022 Aug 25;17(8):e0273482. doi: 10.1371/journal.pone.0273482. eCollection 2022.
9
Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children.
Nat Commun. 2022 Jul 8;13(1):3937. doi: 10.1038/s41467-022-31600-0.
本文引用的文献
1
Cost-Effective Method to Perform SARS-CoV-2 Variant Surveillance: Detection of Alpha, Gamma, Lambda, Delta, Epsilon, and Zeta in Argentina.
Front Med (Lausanne). 2021 Dec 10;8:755463. doi: 10.3389/fmed.2021.755463. eCollection 2021.
2
Association of Age and Pediatric Household Transmission of SARS-CoV-2 Infection.
JAMA Pediatr. 2021 Nov 1;175(11):1151-1158. doi: 10.1001/jamapediatrics.2021.2770.
3
Comparison of Symptoms and RNA Levels in Children and Adults With SARS-CoV-2 Infection in the Community Setting.
JAMA Pediatr. 2021 Oct 1;175(10):e212025. doi: 10.1001/jamapediatrics.2021.2025. Epub 2021 Oct 4.
4
Analysis of cycle threshold values in SARS-CoV-2-PCR in a long-term study.
J Clin Virol. 2021 May;138:104791. doi: 10.1016/j.jcv.2021.104791. Epub 2021 Mar 10.
5
Household Severe Acute Respiratory Syndrome Coronavirus 2 Transmission and Children: A Network Prospective Study.
Clin Infect Dis. 2021 Sep 15;73(6):e1261-e1269. doi: 10.1093/cid/ciab228.
6
Difference in Severe Acute Respiratory Syndrome Coronavirus 2 Attack Rate Between Children and Adults May Reflect Bias.
Clin Infect Dis. 2022 Jan 7;74(1):152-155. doi: 10.1093/cid/ciab183.
7
Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults.
Sci Rep. 2021 Feb 4;11(1):3044. doi: 10.1038/s41598-021-81934-w.
8
Comparison of Upper Respiratory Viral Load Distributions in Asymptomatic and Symptomatic Children Diagnosed with SARS-CoV-2 Infection in Pediatric Hospital Testing Programs.
J Clin Microbiol. 2020 Dec 17;59(1). doi: 10.1128/JCM.02593-20.
9
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19).
Clin Infect Dis. 2021 Jul 1;73(1):148-150. doi: 10.1093/cid/ciaa1157.
10
Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19).
JAMA Pediatr. 2020 Sep 1;174(9):902-903. doi: 10.1001/jamapediatrics.2020.3651.
Zotero 插件