Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Department of Neurosurgery, Araki Neurosurgical Hospital, Hiroshima, Japan.
Mod Rheumatol Case Rep. 2022 Jun 24;6(2):220-225. doi: 10.1093/mrcr/rxab030.
Giant cell arteritis (GCA) occasionally presents with ischaemic stroke. Generally, symptoms related to GCA or elevated levels of inflammation markers would be a clue for the diagnosis of GCA. However, we encountered a rare case of GCA that presented with recurrent cerebellar infarctions without symptoms related to GCA (headache, fever, or jaw claudication). Furthermore, C-reactive protein levels, measured at the time of two of the stroke attacks, were within the normal range. On physical examination, the temporal arteries were prominent and weakly pulsatile. Temporal artery ultrasonography showed halo signs, and temporal artery biopsy revealed GCA. To our knowledge, this is the first case of GCA presenting with recurrent ischaemic stroke lacking GCA features but diagnosed before death. Considering this case-based review, we suggest that GCA may have been missed in elderly patients with ischaemic stroke, especially in those with posterior circulation infarction. Therefore, physical examination of the temporal arteries, temporal artery ultrasonography, and vessel wall magnetic resonance imaging may be useful in those patients.
巨细胞动脉炎(GCA)偶尔会引起缺血性脑卒中。一般来说,与 GCA 相关的症状或炎症标志物水平升高,会提示 GCA 的诊断。然而,我们遇到了一例罕见的 GCA 病例,其表现为反复发作的小脑梗死,而无与 GCA 相关的症状(头痛、发热或下颌跛行)。此外,在两次脑卒中发作时测量的 C 反应蛋白水平在正常范围内。体格检查时,颞动脉突出且搏动微弱。颞动脉超声显示晕环征,颞动脉活检显示 GCA。据我们所知,这是首例以反复发作性缺血性脑卒中为表现、缺乏 GCA 特征但在死亡前确诊的 GCA 病例。基于本例的回顾性研究,我们建议对于缺血性脑卒中的老年患者,尤其是后循环梗死的患者,可能会漏诊 GCA。因此,颞动脉体格检查、颞动脉超声和血管壁磁共振成像可能对这些患者有用。