Department of Rheumatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Department of Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, UK
BMJ Case Rep. 2021 Dec 8;14(12):e244948. doi: 10.1136/bcr-2021-244948.
Giant cell arteritis (GCA) typically presents with headache, scalp tenderness or visual disturbance. Other symptoms include orofacial pain, constitutional symptoms and ischaemic stroke. An 81-year-old woman with a background of type-2 diabetes and hypertension presented with headache, oral pain and right visual loss. Examination showed hypertension, nodular temporal arteries, reduced visual acuity and suspected oral candida. Inflammatory markers were raised and she was diagnosed with GCA and commenced on corticosteroids. During treatment she developed tongue ulceration, then acute vertigo and incoordination with nystagmus and ataxia. Neuroimaging confirmed bilateral, cerebellar ischaemic strokes and temporal artery biopsy was consistent with GCA. With corticosteroids and secondary prevention of stroke measures she is now functionally independent. Oral pain is an uncommon symptom of GCA and delays in recognition may lead to catastrophic consequences. Clinicians should be aware of uncommon presentations and to optimise additional ischaemic stroke risk-factors.
巨细胞动脉炎(GCA)通常表现为头痛、头皮触痛或视觉障碍。其他症状包括口面疼痛、全身症状和缺血性脑卒中。一位 81 岁的女性,有 2 型糖尿病和高血压病史,表现为头痛、口腔疼痛和右眼视力丧失。检查发现高血压、颞动脉结节、视力下降和疑似口腔念珠菌病。炎症标志物升高,诊断为 GCA,并开始使用皮质类固醇治疗。在治疗过程中,她出现了舌溃疡,然后出现急性眩晕、眼球震颤和共济失调。神经影像学证实为双侧小脑缺血性脑卒中,颞动脉活检符合 GCA。通过皮质类固醇和脑卒中二级预防措施,她现在功能独立。口腔疼痛是 GCA 的一种不常见症状,延迟识别可能导致灾难性后果。临床医生应注意不常见的表现,并优化其他缺血性脑卒中风险因素。