Heterocyclic Chemistry Research Laboratory, Chemistry Department, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
ChemistryOpen. 2021 Dec;10(12):1186-1196. doi: 10.1002/open.202100221.
Polymer-coated magnetic nanoparticles are emerging as a useful tool for a variety of applications, including catalysis. In the present study, fucoidan-coated magnetic graphene oxide was synthesized using a natural sulfated polysaccharide. The prepared BaFe O @GO@Fu (Fu=fucoidan, GO=graphene oxide) was characterized using Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) analysis, vibrating sample magnetometry (VSM), thermogravimetric analysis (TGA), Raman spectroscopy, and X-ray diffraction (XRD). The catalytic proficiency of BaFe O @GO@Fu was investigated in the synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives. Excellent turnover numbers (TON) and turnover frequencies (TOF) (6330 and 25320 h ) testify to the high efficiency of the catalyst. Moreover, the antimicrobial activity of BaFe O @GO@Fu was evaluated against Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus) through the Agar well diffusion method, indicating that BaFe O @GO@Fu has antibacterial activity against S. aureus.
聚合物包覆的磁性纳米粒子作为一种有用的工具在各种应用中崭露头角，包括催化。在本研究中，使用天然硫酸化多糖合成了褐藻胶包覆的磁性氧化石墨烯。通过傅里叶变换红外（FTIR）光谱、扫描电子显微镜（SEM）、透射电子显微镜（TEM）、能量色散 X 射线（EDX）分析、振动样品磁强计（VSM）、热重分析（TGA）、拉曼光谱和 X 射线衍射（XRD）对制备的 BaFeO@GO@Fu（Fu=褐藻胶，GO=氧化石墨烯）进行了表征。研究了 BaFeO@GO@Fu 在合成 1,4-二氢吡啶和多氢喹啉衍生物中的催化性能。高转化率（TON）和转化率（TOF）（6330 和 25320 h）证明了催化剂的高效性。此外，还通过琼脂孔扩散法评估了 BaFeO@GO@Fu 对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的抗菌活性，表明 BaFeO@GO@Fu 对金黄色葡萄球菌具有抗菌活性。
