Synthesis of ZIF-8/ZnFeO/GO-OSOH nanocomposite as a superior and reusable heterogeneous catalyst for the preparation of pyrimidine derivatives and investigation of their antimicrobial activities.

In this report, we synthesized some pyrimidine derivatives by multi-component reaction of urea, benzaldehydes, and 1,3-indandione in the presence of ZIF-8/ZnFeO/GO-OSOH nanocomposite under reflux conditions. Initially, graphene oxide was prepared from graphite, and then it was sulfonated using ClOSOH. Next, GO-OSOH nanosheets were used to support ZIF-8/ZnFeO nanostructure. The construction of the synthesized structure was established using different spectral techniques such as X-ray crystallography (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX/Mapping), Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), and Brunauer-Emmett-Teller (BET). The present method provides various benefits including the efficiency of outcomes, easy separation of the catalyst, and excellent yield of the products within short reaction times. Moreover, the antibacterial activities of pyrimidine derivatives were investigated via the agar-well diffusion method on gram-negative () and gram-positive () bacteria and the obtained results illustrated reasonable effects.