Moura Alexandra, Lefrancq Noémie, Wirth Thierry, Leclercq Alexandre, Borges Vítor, Gilpin Brent, Dallman Timothy J, Frey Joachim, Franz Eelco, Nielsen Eva M, Thomas Juno, Pightling Arthur, Howden Benjamin P, Tarr Cheryl L, Gerner-Smidt Peter, Cauchemez Simon, Salje Henrik, Brisse Sylvain, Lecuit Marc
Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit, Paris, France.
Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France.
Sci Adv. 2021 Dec 3;7(49):eabj9805. doi: 10.1126/sciadv.abj9805. Epub 2021 Dec 1.
The bacterial foodborne pathogen clonal complex 1 (-CC1) is the most prevalent clonal group associated with human listeriosis and is strongly associated with cattle and dairy products. Here, we analyze 2021 isolates collected from 40 countries, covering -CC1 first isolation to present days, to define its evolutionary history and population dynamics. We show that -CC1 spread worldwide from North America following the Industrial Revolution through two waves of expansion, coinciding with the transatlantic livestock trade in the second half of the 19th century and the rapid growth of cattle farming and food industrialization in the 20th century. In sharp contrast to its global spread over the past century, transmission chains are now mostly local, with limited inter- and intra-country spread. This study provides an unprecedented insight into phylogeography and population dynamics and highlights the importance of genome analyses for a better control of pathogen transmission.
食源性病原体克隆复合体1（CC1）是与人类李斯特菌病相关的最普遍的克隆群，并且与牛和乳制品密切相关。在此，我们分析了从40个国家收集的2021株分离株，涵盖了CC1从首次分离到如今的情况，以确定其进化历史和种群动态。我们表明，CC1在工业革命后从北美通过两波扩张传播到全球，这与19世纪下半叶的跨大西洋牲畜贸易以及20世纪养牛业和食品工业化的快速发展相吻合。与其在过去一个世纪的全球传播形成鲜明对比的是，现在传播链大多是局部的，国家间和国家内的传播有限。这项研究为系统地理学和种群动态提供了前所未有的见解，并强调了基因组分析对于更好地控制病原体传播的重要性。
