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2
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Cytotoxic T lymphocyte response to minor H-42a alloantigen in H-42b mice: clonal inactivation of the precursor cytotoxic T lymphocytes by veto-like spleen cells that express the H-42a antigen.H-42b小鼠对次要H-42a同种抗原的细胞毒性T淋巴细胞反应：表达H-42a抗原的类否决脾细胞对细胞毒性T淋巴细胞前体的克隆失活。
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Monoclonal antibodies against an H-2Kb-specific cytotoxic T cell clone detect several clone-specific molecules.针对H-2Kb特异性细胞毒性T细胞克隆的单克隆抗体可检测到几种克隆特异性分子。
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Recognition of H-2Kb mutant target cells by Moloney virus-specific cytotoxic T lymphocytes from bm13 (H-2Db mutant) mice. I. Full recognition of Kbm11 by Kb-restricted CTL.来自bm13（H-2Db突变体）小鼠的莫洛尼病毒特异性细胞毒性T淋巴细胞对H-2Kb突变靶细胞的识别。I. Kb限制性细胞毒性T淋巴细胞对Kbm11的完全识别。
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Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule.一种源自H-2Kb的肽对同种异体识别的抑制作用，是主要组织相容性复合体分子上存在T细胞结合区域的证据。
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Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads.刀豆球蛋白 A 固定化载体珠上肿瘤特异性细胞毒性 T 淋巴细胞的生长刺激作用。
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Cell-cell interaction in graft rejection responses: induction of anti-allo-class I H-2 tolerance is prevented by immune responses against allo-class II H-2 antigens coexpressed on tolerogen.移植排斥反应中的细胞间相互作用：针对共表达于耐受原上的同种异体II类H-2抗原的免疫反应可阻止抗同种异体I类H-2耐受性的诱导。
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本文引用的文献

1
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.分泌针对小鼠H-2和Ia抗原的单克隆抗体的杂交瘤细胞系。
J Immunol. 1980 Feb;124(2):533-40.
2
History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony.来自C57BL/6Kh群体的H-2Kb突变体的历史和谱系。
Immunogenetics. 1982;15(2):177-85. doi: 10.1007/BF00621950.
3
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Lyt表型的意义：Lyt2抗体可阻断识别1类主要组织相容性复合体抗原的T细胞的活性，无论其功能如何。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7101-5. doi: 10.1073/pnas.78.11.7101.
4
Lyt phenotypes of primary cytotoxic T cells generated across the A and E region of the H-2 complex.在H-2复合体的A区和E区产生的原发性细胞毒性T细胞的Lyt表型。
Eur J Immunol. 1981 Jun;11(6):499-504. doi: 10.1002/eji.1830110611.
5
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.抗小鼠主要组织相容性复合体（MHC）抗原的单克隆抗体。III. 与H-2b单倍型抗原发生反应的杂交瘤抗体揭示了同种型表达的遗传控制。
J Immunol. 1981 Jan;126(1):317-21.
6
Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.H-2 限制性 T 细胞的抗原识别。II. 一种替代加工抗原的胰蛋白酶消化卵清蛋白肽。
J Immunol. 1984 Oct;133(4):2067-74.
7
Mouse alloantibodies capable of blocking cytotoxic T cell function. V. The majority of I region-specific CTL are Lyt-2+ but are relatively resistant to anti-Lyt-2 blocking.能够阻断细胞毒性T细胞功能的小鼠同种抗体。V. 大多数I区特异性CTL是Lyt-2+，但对抗Lyt-2阻断相对耐药。
J Immunol. 1984 Feb;132(2):578-83.
8
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.被单克隆抗体GK1.5识别的、命名为L3T4a的鼠类抗原决定簇的特性：功能性T细胞克隆对L3T4a的表达似乎主要与II类主要组织相容性复合体（MHC）抗原反应性相关。
Immunol Rev. 1983;74:29-56. doi: 10.1111/j.1600-065x.1983.tb01083.x.
9
T cell clones specific for hybrid I-A molecules. Discrimination with monoclonal anti-I-Ak antibodies.针对杂交I-A分子的T细胞克隆。用单克隆抗I-Ak抗体进行鉴别。
J Exp Med. 1982 Oct 1;156(4):1186-94. doi: 10.1084/jem.156.4.1186.
10
Specificity, phenotype, and precursor frequency of primary cytolytic T lymphocytes specific for class II major histocompatibility antigens.针对II类主要组织相容性抗原的原发性细胞溶解性T淋巴细胞的特异性、表型及前体细胞频率。
J Immunol. 1985 Sep;135(3):1610-5.

在I类抗原背景下识别I-A区产物的克隆化细胞毒性T淋巴细胞。

Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

作者信息

Shinohara N, Bluestone J A, Sachs D H

出版信息

J Exp Med. 1986 Apr 1;163(4):972-80. doi: 10.1084/jem.163.4.972.

DOI:10.1084/jem.163.4.972
PMID:3485175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188072/
Abstract

Cloned CTLs QM3 and QM7 isolated from a bulk CTL line B10.QBR anti-B10.MBR recognized a combination of the H-2Kb molecule and an I-Ak subregion gene product. Such a combinatorial specificity was revealed by complementation of the target antigen in F1 animals between two negative parental strains carrying H-2Kb and I-Ak, respectively. We confirmed the involvement of the H-2Kb molecule by blocking killing with anti-Kb mAb and failure of certain mutant H-2Kb genes to complement with I-Ak to generate the determinant in F1 animals. Although the nature of the I-Ak subregion gene product is not definitive, there was a correlation between the expression of Ia antigens on the cell surface and susceptibility of the cells to lysis by these CTLs, suggesting that it is the classical I-Ak class II antigen.

摘要

从大量细胞毒性T淋巴细胞（CTL）系B10.QBR抗B10.MBR中分离出的克隆CTL QM3和QM7识别H-2Kb分子和I-Ak亚区基因产物的组合。这种组合特异性通过分别携带H-2Kb和I-Ak的两个阴性亲本品系之间F1动物中靶抗原的互补得以揭示。我们通过用抗Kb单克隆抗体阻断杀伤以及某些突变的H-2Kb基因无法与I-Ak互补以在F1动物中产生决定簇，证实了H-2Kb分子的参与。尽管I-Ak亚区基因产物的性质尚不明确，但细胞表面Ia抗原的表达与这些CTL对细胞裂解的敏感性之间存在相关性，这表明它是经典的I-Ak II类抗原。