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在I类抗原背景下识别I-A区产物的克隆化细胞毒性T淋巴细胞。

Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

作者信息

Shinohara N, Bluestone J A, Sachs D H

出版信息

J Exp Med. 1986 Apr 1;163(4):972-80. doi: 10.1084/jem.163.4.972.

DOI:10.1084/jem.163.4.972
PMID:3485175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188072/
Abstract

Cloned CTLs QM3 and QM7 isolated from a bulk CTL line B10.QBR anti-B10.MBR recognized a combination of the H-2Kb molecule and an I-Ak subregion gene product. Such a combinatorial specificity was revealed by complementation of the target antigen in F1 animals between two negative parental strains carrying H-2Kb and I-Ak, respectively. We confirmed the involvement of the H-2Kb molecule by blocking killing with anti-Kb mAb and failure of certain mutant H-2Kb genes to complement with I-Ak to generate the determinant in F1 animals. Although the nature of the I-Ak subregion gene product is not definitive, there was a correlation between the expression of Ia antigens on the cell surface and susceptibility of the cells to lysis by these CTLs, suggesting that it is the classical I-Ak class II antigen.

摘要

从大量细胞毒性T淋巴细胞（CTL）系B10.QBR抗B10.MBR中分离出的克隆CTL QM3和QM7识别H-2Kb分子和I-Ak亚区基因产物的组合。这种组合特异性通过分别携带H-2Kb和I-Ak的两个阴性亲本品系之间F1动物中靶抗原的互补得以揭示。我们通过用抗Kb单克隆抗体阻断杀伤以及某些突变的H-2Kb基因无法与I-Ak互补以在F1动物中产生决定簇，证实了H-2Kb分子的参与。尽管I-Ak亚区基因产物的性质尚不明确，但细胞表面Ia抗原的表达与这些CTL对细胞裂解的敏感性之间存在相关性，这表明它是经典的I-Ak II类抗原。

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本文引用的文献

1
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.分泌针对小鼠H-2和Ia抗原的单克隆抗体的杂交瘤细胞系。
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2
History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony.来自C57BL/6Kh群体的H-2Kb突变体的历史和谱系。
Immunogenetics. 1982;15(2):177-85. doi: 10.1007/BF00621950.
3
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Lyt表型的意义：Lyt2抗体可阻断识别1类主要组织相容性复合体抗原的T细胞的活性，无论其功能如何。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7101-5. doi: 10.1073/pnas.78.11.7101.
4
Lyt phenotypes of primary cytotoxic T cells generated across the A and E region of the H-2 complex.在H-2复合体的A区和E区产生的原发性细胞毒性T细胞的Lyt表型。
Eur J Immunol. 1981 Jun;11(6):499-504. doi: 10.1002/eji.1830110611.
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Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.抗小鼠主要组织相容性复合体（MHC）抗原的单克隆抗体。III. 与H-2b单倍型抗原发生反应的杂交瘤抗体揭示了同种型表达的遗传控制。
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J Immunol. 1985 Sep;135(3):1610-5.

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