来自脆弱拟杆菌的对氧亚氨基头孢菌素具有活性的β-内酰胺酶。
Beta-lactamases from Bacteroides fragilis active against oximino-cephalosporins.
作者信息
Werner R G, Appel K R, Erne A M
出版信息
Arzneimittelforschung. 1985;35(1A):348-50.
Four clinical isolates of Bacteroides fragilis were resistant to penicillins and cephalosporins with exception to 7-alpha-methoxy cephalosporins such as latamoxef (moxalactam) and cefoxitin. In contrast the 6-alpha-methoxy penicillin temocillin was not active. The beta-lactam resistance correlates with the presence of two beta-lactamases with an isoelectric point (IEP) = 4.9 and 5.4, respectively. The necessity of antimicrobial susceptibility testing before the therapy of infections with anaerobic bacteria is discussed.
脆弱拟杆菌的4株临床分离株对青霉素和头孢菌素耐药，但对7-α-甲氧基头孢菌素如拉氧头孢（羟羧氧酰胺菌素）和头孢西丁敏感。相比之下，6-α-甲氧基青霉素替莫西林无活性。β-内酰胺耐药性与分别具有等电点（IEP）=4.9和5.4的两种β-内酰胺酶的存在相关。讨论了在治疗厌氧菌感染之前进行抗菌药敏试验的必要性。
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