Martin C, Dubreuil L, Sedallian A, Romond C
Laboratoire de Bactériologie, Centre Hospitalier d'Annecy.
Pathol Biol (Paris). 1990 May;38(5):470-3.
One hundred and thirty three strains of Bacteroides fragilis group isolated from clinical specimen were tested for beta-lactamase activity against five beta-lactam antibiotics, ampicillin, cefaloridin, cefuroxime, cefotaxime and cefoxitin. The Minimal Inhibitory Concentration of antibiotics was determined using the agar dilution method. Beta-lactamase production was detected by a microbiological method in 128 of the 133 (96%) strains. The detected beta-lactamases had a broad-spectrum activity, hydrolyzing both penicillins and cephalosporins (101 strains). Some strains had a wide activity against beta-lactam antibiotics, including cefoxitin (7 strains); among these strains, 3 were found hydrolyzing imipenem.
对从临床标本中分离出的133株脆弱拟杆菌属菌株进行了针对5种β-内酰胺抗生素（氨苄西林、头孢噻啶、头孢呋辛、头孢噻肟和头孢西丁）的β-内酰胺酶活性检测。采用琼脂稀释法测定抗生素的最低抑菌浓度。通过微生物学方法在133株菌株中的128株（96%）检测到β-内酰胺酶产生。检测到的β-内酰胺酶具有广谱活性，能水解青霉素和头孢菌素（101株）。一些菌株对β-内酰胺抗生素具有广泛活性，包括头孢西丁（7株）；在这些菌株中，发现3株能水解亚胺培南。
