Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Prev Res (Phila). 2021 Dec;14(12):1055-1060. doi: 10.1158/1940-6207.CAPR-21-0016.
An unacceptable number of women continue to die from cervical cancer around the world each year. Despite established primary and secondary prevention measures, and a natural history of disease which provides a long latent phase in which to intervene, there are still more than 500,000 women diagnosed with cervical cancer globally each year, and 300,000 related deaths. Approximately 90% of these cervical cancer cases and deaths occur in low- and middle-income countries (LMIC). The World Health Organization (WHO) recently launched a that outlines 3 key steps: (i) vaccination against human papillomavirus (HPV); (ii) cervical screening; and (iii) treatment of precancerous lesions and management of invasive cancer. Successful implementation of all 3 steps could reduce more than 40% of new cervical cancer cases and 5 million related deaths by 2050. However, this initiative requires high level commitment to HPV immunization programs, innovative approaches to screening, and strengthening of health systems to provide treatment for both precancerous lesions as well as invasive cervical cancer.
尽管已经有了既定的一级和二级预防措施，并且疾病的自然史提供了一个很长的潜伏期，可以进行干预，但每年仍有超过 50 万名女性被诊断出患有宫颈癌，相关死亡人数达到 30 万。这些宫颈癌病例和死亡中有大约 90%发生在低收入和中等收入国家（LMIC）。世界卫生组织（WHO）最近发布了一项，概述了 3 个关键步骤：（i）接种人乳头瘤病毒（HPV）疫苗；（ii）宫颈筛查；和（iii）癌前病变的治疗和浸润性癌症的管理。到 2050 年，成功实施所有 3 个步骤可以减少超过 40%的新宫颈癌病例和 500 万相关死亡。然而，这一倡议需要高度承诺实施 HPV 免疫计划，创新的筛查方法，以及加强卫生系统，为癌前病变以及浸润性宫颈癌提供治疗。
