Müller J
Schweiz Med Wochenschr. 1986 Mar 1;116(9):262-5.
According to the current view a semiautonomously ACTH-producing pituitary microadenoma is the true cause of pituitary-dependent Cushing's syndrome in most instances. Only exceptionally does the disease seem to be caused by a functional pituitary or hypothalamic disturbance of cortisol regulation. A newly discovered rare etiology is ectopic production of CRF. Cushing's syndrome is still most reliably diagnosed by abnormal adrenocortical function tests based on corticosteroid determinations. However, determination of plasma ACTH concentrations and computer-assisted tomography of the pituitary or adrenal glands have become useful tools in differentiating the various forms of Cushing's syndrome. Although a considerable number of available drugs provide effective chemotherapy for Cushing's syndrome, surgical elimination of ACTH-producing or cortisol-producing tumors is still the therapy of choice in most cases.
根据目前的观点，在大多数情况下，产生促肾上腺皮质激素（ACTH）的半自主性垂体微腺瘤是垂体依赖性库欣综合征的真正病因。只有在极少数情况下，该疾病似乎是由垂体或下丘脑对皮质醇调节的功能性紊乱引起的。一种新发现的罕见病因是促肾上腺皮质激素释放因子（CRF）的异位产生。库欣综合征仍然最可靠地通过基于皮质类固醇测定的异常肾上腺皮质功能测试来诊断。然而，血浆促肾上腺皮质激素浓度的测定以及垂体或肾上腺的计算机断层扫描已成为区分各种形式库欣综合征的有用工具。尽管有相当数量的现有药物可为库欣综合征提供有效的化疗，但在大多数情况下，手术切除产生促肾上腺皮质激素或产生皮质醇的肿瘤仍然是首选治疗方法。
