Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China.
Br J Cancer. 2022 Mar;126(5):815-821. doi: 10.1038/s41416-021-01645-x. Epub 2021 Dec 1.
Little prospective evidence exists about whether a combination of healthy lifestyle factors is related to a considerable reduction of liver cancer risk.
Based on the prospective China Kadoorie Biobank (CKB) cohort with a total of 492,640 Chinese adults, we examined the associations of five lifestyle factors with risk of liver cancer. Low-risk lifestyle factors were defined as non-smoking, non-drinking, median or higher level of physical activity, a healthy diet, and waist-to-hip ratio (WHR) < 0.90 for men and <0.85 for women.
During a median of 10.12 years of follow-up, 2529 liver cancer events were observed. There was a significant decrease in liver cancer risk with the increasing of the healthy lifestyle index scores (P < 0.001). Participants with a favourable lifestyle (4 or 5 healthy lifestyle factors) had a 43% reduced liver cancer risk compared with those with an unfavourable lifestyle (0 or 1 healthy lifestyle factor) (HR, 0.57 [95% CI, 0.47-0.68]). The cumulative protective effect of a healthy lifestyle on liver cancer appeared to be more dramatic for patients with hepatitis B surface antigen (HBsAg) positive, the individuals at high risk of liver cancer.
Individuals adhering to a favourable lifestyle was associated with a considerable absolute risk reduction of liver cancer.
关于健康的生活方式因素组合是否与肝癌风险的显著降低有关，目前几乎没有前瞻性证据。
基于前瞻性的中国慢性病前瞻性研究（CKB）队列，该队列共纳入了 492640 名中国成年人，我们研究了 5 种生活方式因素与肝癌风险的关系。低风险的生活方式因素定义为不吸烟、不饮酒、中等或更高水平的身体活动、健康饮食以及男性腰围臀围比（WHR）<0.90，女性<0.85。
在中位随访 10.12 年期间，观察到 2529 例肝癌事件。肝癌风险随着健康生活方式指数评分的增加而显著降低（P<0.001）。与生活方式不良（0 或 1 个健康生活方式因素）的参与者相比，生活方式良好（4 或 5 个健康生活方式因素）的参与者肝癌风险降低了 43%（HR，0.57[95%CI，0.47-0.68]）。健康生活方式对肝癌的累积保护作用对于乙型肝炎表面抗原（HBsAg）阳性、肝癌高危人群的患者似乎更为显著。
坚持健康生活方式与肝癌的绝对风险显著降低有关。
