炎症评分、健康生活方式与心血管疾病之间的关联：一项全国性队列研究。

Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study.

作者信息

Zhao Han-Qing, Lv Jia-Le, Gao Yuan-Zhi, Hu Bo, Du Zong-Da, Wang Yan, Wang Mei-Lin, Hou Meng-Di, Li Fang, Xing Xue, Sun Ming-Hui

机构信息

Hunan Provincial Center for Disease Control and Prevention, Changsha, China.

The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

出版信息

Front Nutr. 2025 Feb 20;12:1534458. doi: 10.3389/fnut.2025.1534458. eCollection 2025.

DOI:10.3389/fnut.2025.1534458

PMID:40051968

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11882400/

Abstract

BACKGROUND

The inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. However, the relationship between inflammation score and cardiovascular disease (CVD) is unclear. Thus, we aimed to explore the association of inflammatory score with CVD, as well as to evaluate whether adhering to a healthy lifestyle could alleviate this association.

METHODS

We analyzed 6,164 participants aged ≥45 years who entered a prospective cohort study of the China Longitudinal Study of Health and Retirement (CHARLS) between 2011 and 2012 and were followed up for CVD incidence untill 2018. The inflammatory score was measured by summing of the Z-scores for C-reactive protein and white blood cell count at baseline. The healthy lifestyle score was calculated by four factors, smoking status, alcohol consumption, body mass index, and sleep duration. Cox proportional hazard models were utilized to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of CVD.

RESULTS

During the 7-year follow-up period, there were 761 incident cases of CVD. Compared with the lowest tertiles, the highest inflammatory score was associated with an elevated risk of CVD (HR = 1.25, 95% CI = 1.04-1.49). Compared to the unhealthy lifestyle, participants adhered to a healthy lifestyle was inversely associated with CVD risk (HR = 0.74, 95% CI = 0.60-0.93). Of note, when participants adhered to a healthy lifestyle, the higher inflammatory score was no longer significantly correlated with CVD risk (HR = 1.00, 95% CI = 0.76-1.34). Additionally, a multiplicative interaction was detected between inflammatory score and healthy lifestyle score for CVD risk ( interaction <0.05).

CONCLUSION

The inflammation score was associated with higher risk of CVD incidence, but adherence to a healthy lifestyle may mitigate the adverse association of inflammation score and CVD among the middle-aged and older participants.

摘要

背景

炎症评分目前被视为综合评估炎症状态的可靠综合指标。然而，炎症评分与心血管疾病（CVD）之间的关系尚不清楚。因此，我们旨在探讨炎症评分与CVD的关联，并评估坚持健康的生活方式是否可以减轻这种关联。

方法

我们分析了6164名年龄≥45岁的参与者，他们于2011年至2012年进入中国健康与养老追踪调查（CHARLS）的前瞻性队列研究，并随访至2018年的CVD发病率。炎症评分通过将基线时C反应蛋白和白细胞计数的Z评分相加来测量。健康生活方式评分由吸烟状况、饮酒量、体重指数和睡眠时间四个因素计算得出。采用Cox比例风险模型计算CVD发病率的风险比（HR）和95%置信区间（CI）。

结果

在7年的随访期内，有761例CVD发病病例。与最低三分位数相比，最高炎症评分与CVD风险升高相关（HR = 1.25，95%CI = 1.04 - 1.49）。与不健康的生活方式相比，坚持健康生活方式的参与者与CVD风险呈负相关（HR = 0.74，95%CI = 0.60 - 0.93）。值得注意的是，当参与者坚持健康生活方式时，较高的炎症评分与CVD风险不再显著相关（HR = 1.00，95%CI = 0.76 - 1.34）。此外，检测到炎症评分与健康生活方式评分之间存在CVD风险的相乘交互作用（交互作用P<0.05）。