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参芪苡术汤抗胃癌有效成分及关键通路的鉴定：网络药理学研究与实验验证

Identification of the Active Constituents and Significant Pathways of Shen-qi-Yi-zhu Decoction on Antigastric Cancer: A Network Pharmacology Research and Experimental Validation.

作者信息

Zeng Shuhong, Yu Zhibao, Xu Xintian, Liu Yuanjie, Li Jiepin, Zhao Danya, Song Changjuan, Lu Haixia, Zhao Yudong, Lu Weimin, Zou Xi

机构信息

Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, China.

No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.

出版信息

Evid Based Complement Alternat Med. 2021 Nov 22;2021:6642171. doi: 10.1155/2021/6642171. eCollection 2021.

DOI:10.1155/2021/6642171
PMID:34853601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8629626/
Abstract

Shen-qi-Yi-zhu decoction (SQYZD) is an empirical prescription with antigastric cancer (GC) property created by Xu Jing-fan, a National Chinese Medical Master. However, its underlying mechanisms are still unclear. Based on network pharmacology and experimental verification, this study puts forward a systematic method to clarify the anti-GC mechanism of SQYZD. The active ingredients of SQYZD and their potential targets were acquired from the TCMSP database. The target genes related to GC gathered from GeneCards, DisGeNET, OMIM, TTD, and DrugBank databases were imported to establish protein-protein interaction (PPI) networks in GeneMANIA. Cytoscape was used to establish the drug-ingredients-targets-disease network. The hub target genes collected from the SQYZD and GC were parsed via GO and KEGG analysis. Our findings from network pharmacology were successfully validated using an HGC27 cell model experiment. In a word, this study proves that the combination of network pharmacology and experiments is effective in clarifying the potential molecular mechanism of traditional Chinese medicine (TCM).

摘要

参芪苡术汤（SQYZD）是国医大师徐景藩创制的具有抗胃癌（GC）作用的经验方。然而，其潜在机制尚不清楚。基于网络药理学和实验验证，本研究提出了一种阐明参芪苡术汤抗胃癌机制的系统方法。从中药系统药理学数据库（TCMSP）获取参芪苡术汤的活性成分及其潜在靶点。从GeneCards、DisGeNET、OMIM、TTD和DrugBank数据库收集的与胃癌相关的靶基因被导入到GeneMANIA中建立蛋白质-蛋白质相互作用（PPI）网络。使用Cytoscape建立药物-成分-靶点-疾病网络。通过基因本体论（GO）和京都基因与基因组百科全书（KEGG）分析解析从参芪苡术汤和胃癌中收集的枢纽靶基因。我们利用HGC27细胞模型实验成功验证了网络药理学的研究结果。总之，本研究证明网络药理学与实验相结合在阐明中药潜在分子机制方面是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/5f93a9ef80fd/ECAM2021-6642171.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/91b9f37dd983/ECAM2021-6642171.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/d36eb59b63f4/ECAM2021-6642171.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/45fa3920e898/ECAM2021-6642171.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/5f93a9ef80fd/ECAM2021-6642171.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/91b9f37dd983/ECAM2021-6642171.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/d36eb59b63f4/ECAM2021-6642171.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/45fa3920e898/ECAM2021-6642171.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bda/8629626/5f93a9ef80fd/ECAM2021-6642171.004.jpg

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