Yang Yang, Zhang Zi-Jian, Wen Yu, Xiong Li, Huang Yun-Peng, Wang Yong-Xiang, Liu Kai
Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
World J Gastrointest Oncol. 2021 Nov 15;13(11):1668-1679. doi: 10.4251/wjgo.v13.i11.1668.
Pancreatic cancer is a highly lethal malignancy with low resection and survival rates and is not sensitive to radiotherapy and chemotherapy. Ferroptosis is a novel form of nonapoptotic regulated cell death characterized by the accumulation of lipid peroxides and reactive oxygen species involved in iron metabolism. Ferroptosis has a significant role in the occurrence and development of various tumors. Previous studies have shown that regulating ferroptosis-induced cell death inhibited tumor growth in pancreatic cancer and was synergistic with other antitumor drugs to improve treatment sensitivity. Herein, we discuss the mechanism, inducers, and developments of ferroptosis in pancreatic cancer to provide new strategies for the treatment of the malignancy.
胰腺癌是一种极具致死性的恶性肿瘤，其切除率和生存率较低，且对放疗和化疗不敏感。铁死亡是一种新型的非凋亡性程序性细胞死亡形式，其特征是脂质过氧化物和参与铁代谢的活性氧积累。铁死亡在各种肿瘤的发生和发展中具有重要作用。先前的研究表明，调节铁死亡诱导的细胞死亡可抑制胰腺癌的肿瘤生长，并与其他抗肿瘤药物协同作用以提高治疗敏感性。在此，我们讨论胰腺癌中铁死亡的机制、诱导因素及进展，为治疗这种恶性肿瘤提供新策略。
