Curtin Louise, Conway Marie C, Kilbane Mark T, McKenna Malachi J, McAuliffe Fionnuala M
UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Department of Clinical Chemistry, St. Vincent's University Hospital, Dublin 4, Ireland.
Osteoporos Int. 2022 May;33(5):1165-1170. doi: 10.1007/s00198-021-06250-5. Epub 2021 Dec 1.
Maternal nutrition during pregnancy plays a role in offspring bone health. In a prospective cohort study, offspring bone mineral density at 5 years was not associated with maternal calcium intake or maternal bone resorption during pregnancy.
Suboptimal bone mineral density in childhood can result in osteoporosis later in life. We reported previously that lower calcium intake during pregnancy was associated with higher maternal bone resorption during pregnancy and that lower maternal dietary calcium and higher maternal bone resorption in pregnancy were associated with lower maternal bone mineral density (BMD) 5 years later. The current study sought to investigate the effect of both maternal dietary calcium intake and maternal bone resorption during pregnancy on offspring BMD at 5 years.
Data collected as part of the ROLO longitudinal cohort study (n = 103, mother-child dyads) were used in the current analysis. ROLO started as a randomised controlled trial of a low glycemic index diet during second pregnancy in women with macrosomia in first pregnancy in order to prevent recurrence of macrosomia. Maternal dietary intakes were assessed using 3-day food diaries completed during each trimester of pregnancy. Bone resorption in early and late pregnancy was calculated through urinary excretion of cross-linked N-telopeptides (uNTX). Offspring whole-body BMD at 5 years was measured using dual-energy X-ray absorptiometry.
Offspring BMD at 5 years correlated with offspring body mass index (r = .385; p < .001) and offspring BMD was higher in boys than girls (t = 2.91; p = .004). Offspring BMD at 5 years was not associated with either maternal calcium intake or uNTX during pregnancy, after controlling for offspring body mass index and offspring sex.
Offspring BMD at 5 years is not associated with either maternal calcium intake or maternal bone resorption during pregnancy.
孕期母体营养对后代骨骼健康有影响。在一项前瞻性队列研究中，5岁时后代的骨矿物质密度与孕期母体钙摄入量或母体骨吸收无关。
儿童时期骨矿物质密度欠佳可能导致日后患骨质疏松症。我们之前报道过，孕期钙摄入量较低与孕期母体较高的骨吸收有关，且孕期母体膳食钙较低和母体骨吸收较高与5年后母体较低的骨矿物质密度（BMD）有关。本研究旨在探讨孕期母体膳食钙摄入量和母体骨吸收对5岁时后代BMD的影响。
作为ROLO纵向队列研究（n = 103，母婴二元组）一部分收集的数据用于当前分析。ROLO最初是一项针对首次怀孕时患有巨大儿的女性在第二次怀孕时采用低血糖指数饮食的随机对照试验，以预防巨大儿复发。通过孕期每个阶段完成的3天食物日记评估母体膳食摄入量。通过交联N-端肽的尿排泄量（uNTX）计算孕早期和孕晚期的骨吸收。使用双能X线吸收法测量5岁时后代的全身BMD。
5岁时后代BMD与后代体重指数相关（r = 0.385；p < 0.001），且男孩的后代BMD高于女孩（t = 2.91；p = 0.004）。在控制后代体重指数和后代性别后，5岁时后代BMD与孕期母体钙摄入量或uNTX均无关。
5岁时后代BMD与孕期母体钙摄入量或母体骨吸收均无关。
