Yi Xiao, Liu Fan, Gao Kunjie, Chen Feng, Wang Yifeng, Li Huayan, Wang Xuefeng, Huang Yi, Fu Huijiao, Zhou Weijie, Fan Jun-Bing, Wang Shutao, Gao Yi
Research Centre for Artificial Organ and Tissue Engineering & Institute of Regenerative Medicine, Department of Hepatobiliary Surgery II, Zhujiang Hospital, Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510280, P. R. China.
Department of Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, P. R. China.
Adv Mater. 2022 Feb;34(8):e2106510. doi: 10.1002/adma.202106510. Epub 2022 Jan 20.
Uterine factor infertility is increasingly common in modern society and has severely affected human life and health. However, the existing biomaterial scaffold-mediated systems remain limited in efficient uterus recovery, leading to low pregnancy rate and live births. Here, reconstructable uterus-derived materials (RUMs) are demonstrated by combining uterus-derived extracellular matrix and seeded chorionic villi mesenchymal stem cells for uterus recovery, achieving highly efficient live births in rats with severe uterine injury. The RUMs can be designed into different states (such as, liquid RUMs and solid RUMs) and shapes (such as, cuboid, triangular-prism, and cube) in terms of requirements. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction, as well as, accelerate wound healing by constructing a physical barrier and secreting cytokines, allowing efficient uterus recovery. The injured uterus nearly achieves complete recovery after treating with the RUMs and has normal pregnancies for supporting fetal development and live births, similar to the normal rats. The study provides a regenerative medicine therapeutics for uterine factor infertility.
子宫因素导致的不孕症在现代社会中越来越普遍，严重影响了人类的生活和健康。然而，现有的生物材料支架介导系统在子宫有效恢复方面仍然有限，导致妊娠率和活产率较低。在此，通过将子宫来源的细胞外基质与接种的绒毛膜间充质干细胞相结合，展示了可重构子宫衍生材料（RUMs）用于子宫恢复，在严重子宫损伤的大鼠中实现了高效活产。RUMs可以根据需要设计成不同状态（如液体RUMs和固体RUMs）和形状（如长方体、三棱柱和立方体）。RUMs可以有效防止宫腔粘连，促进子宫内膜再生和肌肉胶原蛋白重建，以及通过构建物理屏障和分泌细胞因子加速伤口愈合，从而实现子宫的有效恢复。用RUMs治疗后，受损子宫几乎完全恢复，并能正常妊娠以支持胎儿发育和活产，类似于正常大鼠。该研究为子宫因素不孕症提供了一种再生医学治疗方法。
