Chen Mengyao, Liu Jialin, Lin Jianhong, Zhuang Kai, Shan Yudong, Tiwari Sandip, Jiang Lei, Zhang Jiantao
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Gels. 2025 Mar 8;11(3):188. doi: 10.3390/gels11030188.
Postoperative adhesions are common complications following surgery, often accompanied by pain and inflammation that significantly diminish patients' quality of life. Moreover, managing postoperative adhesions incurs substantial cost, imposing a considerable financial burden on both patients and healthcare systems. Traditional anti-adhesion materials are confronted with limitations, such as inadequate tissue adherence in a moist environment and poor degradability, underscoring the urgent need for more effective solutions. Recently, polysaccharide-based hydrogels have received considerable attention for their potential in preventing postoperative adhesions. The hydrogels not only facilitate wound healing but also effectively reduce inflammation, providing a promising approach to preventing postoperative adhesions. This review provides an extensive analysis of the progress made in the development of polysaccharide-based hydrogels for postoperative anti-adhesion therapy. It highlights their principal benefits, outlines future research trajectories, and addresses the ongoing challenges that need to be overcome.
术后粘连是手术后常见的并发症，常伴有疼痛和炎症，严重降低患者的生活质量。此外，处理术后粘连会产生高昂的费用，给患者和医疗系统带来相当大的经济负担。传统的抗粘连材料存在局限性，如在潮湿环境中组织粘附不足和降解性差，这凸显了对更有效解决方案的迫切需求。最近，基于多糖的水凝胶因其在预防术后粘连方面的潜力而受到广泛关注。这些水凝胶不仅有助于伤口愈合，还能有效减轻炎症，为预防术后粘连提供了一种有前景的方法。本综述对基于多糖的水凝胶在术后抗粘连治疗方面的发展进展进行了广泛分析。它突出了它们的主要优点，概述了未来的研究方向，并探讨了需要克服的当前挑战。
