Griggs T R, Bauman R W, Reddick R L, Read M S, Koch G G, Lamb M A
Arteriosclerosis. 1986 Mar-Apr;6(2):155-65. doi: 10.1161/01.atv.6.2.155.
The development of coronary atherosclerosis in response to acute intimal injury and severe hypercholesterolemia was studied in 18 swine, nine normal and nine with von Willebrand's disease, an inherited disorder affecting platelet-vessel wall interactions. The left anterior descending coronary artery was denuded of endothelium by balloon catheterization, while the circumflex and right coronary arteries served as nonballooned controls. All swine were maintained on a 2% cholesterol diet for 4 months. The extent of atherosclerotic involvement was evaluated from four indices: percent intimal area, percent luminal narrowing, ratio of intimal to medial area, and luminal form. No differences in coronary atherosclerosis were observed between phenotypes in either ballooned or nonballooned vessels, nor were there any differences between ballooned and nonballooned vessels within either phenotype (p greater than 0.05). The major variable affecting coronary atherosclerosis was serum cholesterol. There was a significant positive relationship between serum cholesterol concentration and the extent of intimal lesions (r = 0.62, p = 0.006) that was independent of plasma von Willebrand factor concentration. These findings suggest that severe hypercholesterolemia promotes the development of porcine coronary atherosclerosis through a mechanism(s) that is independent of acute intimal injury or von Willebrand factor-mediated platelet response to injury.
在18头猪身上研究了急性内膜损伤和严重高胆固醇血症引发的冠状动脉粥样硬化的发展情况，其中9头为正常猪，9头患有血管性血友病，这是一种影响血小板与血管壁相互作用的遗传性疾病。通过球囊导管插入术剥脱左前降支冠状动脉的内皮，而回旋支和右冠状动脉作为未进行球囊处理的对照。所有猪均维持4个月的2%胆固醇饮食。从四个指标评估动脉粥样硬化累及程度：内膜面积百分比、管腔狭窄百分比、内膜与中膜面积之比以及管腔形态。在进行球囊处理或未进行球囊处理的血管中，两种表型之间在冠状动脉粥样硬化方面均未观察到差异，并且在任何一种表型内，进行球囊处理和未进行球囊处理的血管之间也没有差异（p大于0.05）。影响冠状动脉粥样硬化的主要变量是血清胆固醇。血清胆固醇浓度与内膜病变程度之间存在显著正相关（r = 0.62，p = 0.006），且与血浆血管性血友病因子浓度无关。这些发现表明，严重高胆固醇血症通过一种独立于急性内膜损伤或血管性血友病因子介导的血小板对损伤反应的机制促进猪冠状动脉粥样硬化的发展。
