Nascimento Camila Sales, Alves Érica Alessandra Rocha, de Melo Celso Pinto, Corrêa-Oliveira Rodrigo, Calzavara-Silva Carlos Eduardo
Grupo de Pesquisa em Imunologia Celular e Molecular, Instituto René Rachou - Fiocruz Minas, Av. Augusto de Lima, 1715 - Barro Preto - Belo Horizonte-MG , 30190-002, Brazil.
Grupo de Polímeros Não-Convencionais, Departamento de Física, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife-PE , 50670-901, Brazil.
Nanomedicine (Lond). 2021 Dec;16(29):2633-2650. doi: 10.2217/nnm-2021-0255. Epub 2021 Dec 2.
Cancer immunotherapy is the most promising trend in oncology, focusing on helping or activating the patient's immune system to identify and fight against cancer. In the last decade, interest in metabolic reprogramming of tumor-associated macrophages from M2-like phenotype (promoting tumor progression) to M1-like phenotypes (suppressing tumor growth) as a therapeutic strategy against cancer has increased considerably. Iron metabolism has been standing out as a target for the reprogramming of tumor-associated macrophages to M1-like phenotype with therapeutic purposes against cancer. Due to the importance of the iron levels in macrophage polarization states, iron oxide nanoparticles can be used to change the activation state of tumor-associated macrophages for a tumor suppressor phenotype and as an anti-tumor strategy.
癌症免疫疗法是肿瘤学中最具前景的发展趋势，其重点在于帮助或激活患者的免疫系统以识别并对抗癌症。在过去十年中，将肿瘤相关巨噬细胞从M2样表型（促进肿瘤进展）重编程为M1样表型（抑制肿瘤生长）作为一种抗癌治疗策略，已引发了人们极大的兴趣。铁代谢作为将肿瘤相关巨噬细胞重编程为具有抗癌治疗目的的M1样表型的靶点，一直备受关注。由于铁水平在巨噬细胞极化状态中的重要性，氧化铁纳米颗粒可用于改变肿瘤相关巨噬细胞的激活状态，使其呈现肿瘤抑制表型，从而作为一种抗肿瘤策略。
