Suzuki N, Sakane T, Ueda Y, Tsunematsu T
Arthritis Rheum. 1986 Feb;29(2):212-9. doi: 10.1002/art.1780290209.
We evaluated B lymphocyte function in 23 patients with Behçet's disease at various stages. The patients with active disease, but not those with inactive disease, were found to have elevated numbers of cells spontaneously secreting immunoglobulin and a decreased B cell response to the T cell-independent B cell mitogen, Staphylococcus aureus Cowan 1. Moreover, B cells from almost all patients with Behçet's disease were unresponsive to the T cell-dependent polyclonal activator, pokeweed mitogen. These results indicate that B cell abnormalities, including some which are associated with disease activity, could be involved in the pathogenesis of Behçet's disease.
我们评估了23例不同阶段白塞病患者的B淋巴细胞功能。结果发现，处于疾病活动期的患者，而非疾病非活动期的患者，自发分泌免疫球蛋白的细胞数量增多，且对T细胞非依赖性B细胞丝裂原——金黄色葡萄球菌Cowan 1的B细胞反应降低。此外，几乎所有白塞病患者的B细胞对T细胞依赖性多克隆激活剂——商陆丝裂原均无反应。这些结果表明，B细胞异常，包括一些与疾病活动相关的异常，可能参与了白塞病的发病机制。
