Nishitani Shoichi, Fukuma Toru, Himori Shogo, Man Youyuan, Shiratori Reiko, Sakata Toshiya
Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Langmuir. 2021 Dec 14;37(49):14369-14379. doi: 10.1021/acs.langmuir.1c02291. Epub 2021 Dec 2.
Aryl diazonium chemistry generates a covalently attached thin film on various materials. This chemistry has diverse applications owing to the stability, ease of functionalization, and versatility of the film. However, the uncontrolled growth into a polyaryl film has limited the controllability of the film's beneficial properties. In this study, we developed a multistep grafting protocol to densify the film while maintaining a thickness on the order of nanometers. This simple protocol enabled the full passivation of a nitrophenyl polyaryl film, completely eliminating the electrochemical reactions at the surface. We then applied this protocol to the grafting of phenylphosphorylcholine films, with which the densification significantly enhanced the antifouling property of the film. Together with its potential to precisely control the density of functionalized surfaces, we believe this grafting procedure will have applications in the development of bioelectrical interfaces.
芳基重氮化学可在各种材料上生成共价连接的薄膜。由于该薄膜具有稳定性、易于功能化以及通用性等特点，这种化学方法有着广泛的应用。然而，不受控制地生长为聚芳基薄膜限制了薄膜有益特性的可控性。在本研究中，我们开发了一种多步接枝方案，以在保持纳米级厚度的同时使薄膜致密化。这个简单的方案能够使硝基苯基聚芳基薄膜完全钝化，彻底消除表面的电化学反应。然后，我们将此方案应用于苯基磷酰胆碱薄膜的接枝，致密化显著增强了薄膜的抗污性能。鉴于其精确控制功能化表面密度的潜力，我们相信这种接枝方法将在生物电界面的开发中得到应用。
