• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于pH传感应用的基于硅纳米线离子敏感场效应晶体管的读出电路方案综述

A Review of Readout Circuit Schemes Using Silicon Nanowire Ion-Sensitive Field-Effect Transistors for pH-Sensing Applications.

作者信息

Joo Jungho, Mo Hyunsun, Kim Seungguk, Shin Seonho, Song Ickhyun, Kim Dae Hwan

机构信息

Department of Intelligent Semiconductor and Display Engineering, Kookmin University, Seoul 02707, Republic of Korea.

School of Electrical Engineering, Kookmin University, Seoul 02707, Republic of Korea.

出版信息

Biosensors (Basel). 2025 Mar 22;15(4):206. doi: 10.3390/bios15040206.

DOI:10.3390/bios15040206
PMID:40277520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12024945/
Abstract

This paper reviews various design approaches for sensing schemes that utilize silicon nanowire (SiNW) ion-sensitive field-effect transistors (ISFETs) for pH-sensing applications. SiNW ISFETs offer advantageous characteristics, including a high surface-to-volume ratio, fast response time, and suitability for integration with complementary metal oxide semiconductor (CMOS) technology. This review focuses on SiNW ISFET-based biosensors in three key aspects: (1) major fabrication processes and device structures; (2) theoretical analysis of key performance parameters in readout circuits such as sensitivity, linearity, noise immunity, and output range in different system configurations; and (3) an overview of existing readout circuits with quantitative evaluations of N-type and P-type current-mirror-based circuits, highlighting their strengths and limitations. Finally, this paper proposes a modified N-type readout scheme integrating an operational amplifier with a negative feedback network to overcome the low sensitivity of conventional N-type circuits. This design enhances gain control, linearity, and noise immunity while maintaining stability. These advancements are expected to contribute to the advancement of the current state-of-the-art SiNW ISFET-based readout circuits.

摘要

本文综述了利用硅纳米线（SiNW）离子敏感场效应晶体管（ISFET）进行pH传感应用的传感方案的各种设计方法。硅纳米线ISFET具有诸多优势特性，包括高表面积与体积比、快速响应时间以及适合与互补金属氧化物半导体（CMOS）技术集成。本综述聚焦于基于硅纳米线ISFET的生物传感器的三个关键方面：（1）主要制造工艺和器件结构；（2）读出电路中关键性能参数的理论分析，如不同系统配置下的灵敏度、线性度、抗噪声能力和输出范围；（3）现有读出电路的概述以及对基于N型和P型电流镜电路的定量评估，突出其优势和局限性。最后，本文提出了一种改进的N型读出方案，将运算放大器与负反馈网络集成，以克服传统N型电路灵敏度低的问题。该设计在保持稳定性的同时增强了增益控制、线性度和抗噪声能力。这些进展有望推动当前基于硅纳米线ISFET的读出电路的技术水平提升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/ea83dc3bd528/biosensors-15-00206-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/87b7b58976c1/biosensors-15-00206-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/bfce25ccc171/biosensors-15-00206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/b461dcafdb9c/biosensors-15-00206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/8a9f6326c9a7/biosensors-15-00206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/7e7a36f6e565/biosensors-15-00206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/cfd86c57a131/biosensors-15-00206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/a83c47ab4fa6/biosensors-15-00206-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/25455fb16ba0/biosensors-15-00206-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/8c827851d0df/biosensors-15-00206-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/97867df7b36a/biosensors-15-00206-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/988aaaa4ff92/biosensors-15-00206-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/1c506538c196/biosensors-15-00206-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/ee5284cc7e9a/biosensors-15-00206-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/b063dd43ddfa/biosensors-15-00206-g013a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/bce0adf5b2eb/biosensors-15-00206-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/a09f79a1fbfa/biosensors-15-00206-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/ea83dc3bd528/biosensors-15-00206-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/87b7b58976c1/biosensors-15-00206-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/bfce25ccc171/biosensors-15-00206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/b461dcafdb9c/biosensors-15-00206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/8a9f6326c9a7/biosensors-15-00206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/7e7a36f6e565/biosensors-15-00206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/cfd86c57a131/biosensors-15-00206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/a83c47ab4fa6/biosensors-15-00206-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/25455fb16ba0/biosensors-15-00206-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/8c827851d0df/biosensors-15-00206-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/97867df7b36a/biosensors-15-00206-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/988aaaa4ff92/biosensors-15-00206-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/1c506538c196/biosensors-15-00206-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/ee5284cc7e9a/biosensors-15-00206-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/b063dd43ddfa/biosensors-15-00206-g013a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/bce0adf5b2eb/biosensors-15-00206-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/a09f79a1fbfa/biosensors-15-00206-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbf0/12024945/ea83dc3bd528/biosensors-15-00206-g016.jpg

相似文献

1
A Review of Readout Circuit Schemes Using Silicon Nanowire Ion-Sensitive Field-Effect Transistors for pH-Sensing Applications.用于pH传感应用的基于硅纳米线离子敏感场效应晶体管的读出电路方案综述
Biosensors (Basel). 2025 Mar 22;15(4):206. doi: 10.3390/bios15040206.
2
Silicon nanowire ion sensitive field effect transistor with integrated Ag/AgCl electrode: pH sensing and noise characteristics.硅纳米线离子敏感场效应晶体管与集成 Ag/AgCl 电极：pH 传感和噪声特性。
Analyst. 2011 Dec 7;136(23):5012-6. doi: 10.1039/c1an15568g. Epub 2011 Oct 10.
3
An FPGA-Based SiNW-FET Biosensing System for Real-Time Viral Detection: Hardware Amplification and 1D CNN for Adaptive Noise Reduction.一种基于现场可编程门阵列的硅纳米线场效应晶体管生物传感系统用于实时病毒检测：硬件放大和一维卷积神经网络用于自适应降噪
Sensors (Basel). 2025 Jan 3;25(1):236. doi: 10.3390/s25010236.
4
Ultra-sensitive nucleic acids detection with electrical nanosensors based on CMOS-compatible silicon nanowire field-effect transistors.基于与 CMOS 兼容的硅纳米线场效应晶体管的电纳米传感器的超灵敏核酸检测。
Methods. 2013 Oct;63(3):212-8. doi: 10.1016/j.ymeth.2013.07.012. Epub 2013 Jul 22.
5
Process Variability in Top-Down Fabrication of Silicon Nanowire-Based Biosensor Arrays.基于硅纳米线的生物传感器阵列的自上而下制造中的工艺变化。
Sensors (Basel). 2021 Jul 29;21(15):5153. doi: 10.3390/s21155153.
6
Silicon Nanowire Field Effect Transistor Sensors with Minimal Sensor-to-Sensor Variations and Enhanced Sensing Characteristics.硅纳米线场效应晶体管传感器具有最小的传感器间差异和增强的传感特性。
ACS Nano. 2018 Jul 24;12(7):6577-6587. doi: 10.1021/acsnano.8b01339. Epub 2018 Jul 5.
7
Design and Fabrication of Silicon Nanowire-Based Biosensors with Integration of Critical Factors: Toward Ultrasensitive Specific Detection of Biomolecules.基于硅纳米线的生物传感器的设计与制作，整合关键因素：朝着生物分子的超灵敏特异性检测迈进。
ACS Appl Mater Interfaces. 2020 Nov 18;12(46):51808-51819. doi: 10.1021/acsami.0c13984. Epub 2020 Nov 3.
8
Monolithic integration of a silicon nanowire field-effect transistors array on a complementary metal-oxide semiconductor chip for biochemical sensor applications.用于生化传感器应用的互补金属氧化物半导体芯片上硅纳米线场效应晶体管阵列的单片集成。
Anal Chem. 2015 Oct 6;87(19):9982-90. doi: 10.1021/acs.analchem.5b02604. Epub 2015 Sep 30.
9
Device Noise Reduction for Silicon Nanowire Field-Effect-Transistor Based Sensors by Using a Schottky Junction Gate.使用肖特基结栅极降低硅纳米线场效应晶体管基传感器的器件噪声。
ACS Sens. 2019 Feb 22;4(2):427-433. doi: 10.1021/acssensors.8b01394. Epub 2019 Jan 25.
10
Label-Free Direct Detection of miRNAs with Poly-Silicon Nanowire Biosensors.利用多晶硅纳米线生物传感器对微小RNA进行无标记直接检测。
PLoS One. 2015 Dec 28;10(12):e0145160. doi: 10.1371/journal.pone.0145160. eCollection 2015.

本文引用的文献

1
Machine Learning-Based Modeling of pH-Sensitive Silicon Nanowire (SiNW) for Ion Sensitive Field Effect Transistor (ISFET).基于机器学习的用于离子敏感场效应晶体管（ISFET）的pH敏感硅纳米线（SiNW）建模
Sensors (Basel). 2024 Dec 18;24(24):8091. doi: 10.3390/s24248091.
2
Ion-sensitive field effect transistor biosensors for biomarker detection: current progress and challenges.离子敏场效应晶体管生物传感器用于生物标志物检测：当前进展和挑战。
J Mater Chem B. 2024 Sep 11;12(35):8523-8542. doi: 10.1039/d4tb00719k.
3
AI-Assisted Detection of Biomarkers by Sensors and Biosensors for Early Diagnosis and Monitoring.
人工智能辅助传感器和生物传感器检测生物标志物进行早期诊断和监测。
Biosensors (Basel). 2024 Jul 22;14(7):356. doi: 10.3390/bios14070356.
4
Control of interface functions in solid-state biosensors for stable detection of molecular recognition.用于稳定检测分子识别的固态生物传感器中界面功能的控制。
Proc Jpn Acad Ser B Phys Biol Sci. 2024;100(1):32-56. doi: 10.2183/pjab.100.004.
5
Application of Silicon Nanowire Field Effect Transistor (SiNW-FET) Biosensor with High Sensitivity.硅纳米线场效应晶体管（SiNW-FET）生物传感器的高灵敏度应用。
Sensors (Basel). 2023 Jul 30;23(15):6808. doi: 10.3390/s23156808.
6
Non-invasive, ultrasensitive detection of glucose in saliva using metal oxide transistors.利用金属氧化物晶体管实现唾液中葡萄糖的无创、高灵敏度检测。
Biosens Bioelectron. 2023 Oct 1;237:115448. doi: 10.1016/j.bios.2023.115448. Epub 2023 Jun 15.
7
Wearable artificial intelligence biosensor networks.可穿戴人工智能生物传感器网络。
Biosens Bioelectron. 2023 Jan 1;219:114825. doi: 10.1016/j.bios.2022.114825. Epub 2022 Oct 21.
8
Advancement and Challenges of Biosensing Using Field Effect Transistors.利用场效应晶体管进行生物传感的进展与挑战。
Biosensors (Basel). 2022 Aug 17;12(8):647. doi: 10.3390/bios12080647.
9
Gold nanoparticle-based signal amplified electrochemiluminescence for biosensing applications.基于金纳米粒子的信号放大电化学发光用于生物传感应用。
Talanta. 2022 Oct 1;248:123611. doi: 10.1016/j.talanta.2022.123611. Epub 2022 May 29.
10
Densification of Diazonium-Based Organic Thin Film as Bioelectrical Interface.基于重氮盐的有机薄膜作为生物电界面的致密化
Langmuir. 2021 Dec 14;37(49):14369-14379. doi: 10.1021/acs.langmuir.1c02291. Epub 2021 Dec 2.