Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, China.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, China.
FEBS Lett. 2022 Feb;596(4):449-464. doi: 10.1002/1873-3468.14249. Epub 2021 Dec 27.
The Hippo signaling pathway is critical for carcinogenesis. However, the roles of the Hippo signaling pathway in the tumor immune microenvironment have been rarely investigated. This study systematically analyzed the relationship between the Hippo signaling pathway and immune cell infiltration across 32 cancer types. Both bioinformatics analyses and biological experiments revealed that the downstream effector of Hippo signaling YAP1 might inhibit CD8+ T cell infiltration by upregulating the expression of the transcription factor CREB1 in uterine corpus endometrial carcinoma. In addition, esophageal carcinoma (ESCA) patients were classified into three subtypes based on the Hippo-immune gene panel. The subtypes of ESCA had distinct characteristics in immune cell infiltration, immune pathways, and prognosis. Thus, this study also reveals a new classification of the immune subtypes with prognostic characteristics in ESCA.
Hippo 信号通路对于癌症发生至关重要。然而，Hippo 信号通路在肿瘤免疫微环境中的作用很少被研究。本研究系统地分析了 Hippo 信号通路与 32 种癌症类型中免疫细胞浸润的关系。生物信息学分析和生物学实验均表明 Hippo 信号通路的下游效应因子 YAP1 可能通过上调转录因子 CREB1 的表达，从而抑制子宫体子宫内膜癌中 CD8+T 细胞的浸润。此外，根据 Hippo-免疫基因谱，将食管癌（ESCA）患者分为三个亚型。ESCA 的亚型在免疫细胞浸润、免疫途径和预后方面具有明显的特征。因此，本研究还揭示了一种具有预后特征的 ESCA 免疫亚型的新分类。
