1st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece.
J Eur Acad Dermatol Venereol. 2022 Jan;36 Suppl 1:11-18. doi: 10.1111/jdv.17531.
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. National and international associations have issued evidence- and consensus-based guidelines to offer clinicians a framework to optimally manage patients with invasive cSCC. Current updated guidelines regarding the recommendations on the management of patients with high-risk and advanced cSCC include EDF/EADO (European) Guidelines 2020, US National Comprehensive Cancer Network guidelines 2021, American Academy of Dermatology guidelines 2018, British Association of Dermatology guidelines 2020 and German guidelines 2020. This review presents the guideline recommendations on the definition of high-risk and advanced cSCC, surgical treatment and safety margins, definitive and adjuvant radiotherapy and systemic treatments. The recommendations across guidelines may converge, diverge or in some cases not be able to provide a recommendation, highlighting open questions to be answered by future studies.
皮肤鳞状细胞癌（cSCC）是第二常见的皮肤癌类型。国家和国际协会已经发布了基于证据和共识的指南，为临床医生提供了一个框架，以最佳地管理侵袭性 cSCC 患者。目前关于高危和晚期 cSCC 患者管理建议的最新指南包括 EDF/EADO（欧洲）指南 2020 年、美国国家综合癌症网络指南 2021 年、美国皮肤病学会指南 2018 年、英国皮肤病学会指南 2020 年和德国指南 2020 年。这篇综述介绍了高危和晚期 cSCC 的定义、手术治疗和安全边界、确定性和辅助放疗以及全身治疗的指南建议。指南中的建议可能会趋同、分歧，或者在某些情况下无法提供建议，突出了需要未来研究回答的悬而未决的问题。
