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用铼-188近距离放射疗法成功治疗唇部皮肤鳞状细胞癌。

Cutaneous squamous cell carcinoma of the lip successfully treated with rhenium-188 brachytherapy.

作者信息

Sabbadini Chiara, Patta Federico, Lorenzon Leda, Farsad Mohsen, Nobile Carla

机构信息

Department of Dermatology, Venereology and Allergology, Hospital of Brunico.

Department of Medical Physics, Hospital of Bolzano.

出版信息

Dermatol Reports. 2023 Jun 14;15(3):9560. doi: 10.4081/dr.2023.9560. eCollection 2023 Sep 12.

DOI:10.4081/dr.2023.9560
PMID:37790652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10543199/
Abstract

Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin cancer. In most cases, non-invasive SCC has a good prognosis and is curable by surgical resection. Nevertheless, a small percentage of patients pose specific management problems due to the technical difficulty of maintaining function and aesthetics because of the size or location of the tumor. An emerging therapeutic approach with high-dose brachytherapy using a nonsealed rhenium-188 resin, commercially known as Rhenium-Skin Cancer Therapy, has been shown to be highly effective in non-invasive carcinoma, up to a thickness of 2-3 mm.

摘要

皮肤鳞状细胞癌(SCC)是第二常见的皮肤癌形式。在大多数情况下,非侵袭性SCC预后良好,可通过手术切除治愈。然而,由于肿瘤的大小或位置导致维持功能和美观存在技术困难,一小部分患者会面临特殊的治疗问题。一种新出现的治疗方法是使用非密封的铼-188树脂进行高剂量近距离放射治疗,商品名为铼皮肤癌治疗,已被证明对厚度达2至3毫米的非侵袭性癌非常有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/7197ac2e8866/dr-15-3-9560-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/c2ad5c5c1bf0/dr-15-3-9560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/e0660bb95a84/dr-15-3-9560-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/7197ac2e8866/dr-15-3-9560-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/c2ad5c5c1bf0/dr-15-3-9560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/e0660bb95a84/dr-15-3-9560-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec3d/10543199/7197ac2e8866/dr-15-3-9560-g003.jpg

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本文引用的文献

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J Eur Acad Dermatol Venereol. 2022 Jan;36 Suppl 1:11-18. doi: 10.1111/jdv.17531.
2
High dose brachytherapy with non sealed Re (rhenium) resin in patients with non-melanoma skin cancers (NMSCs): single center preliminary results.高剂量近距离放射治疗非密封铼(Re)树脂在非黑色素瘤皮肤癌(NMSC)患者中的应用:单中心初步结果。
Eur J Nucl Med Mol Imaging. 2021 May;48(5):1511-1521. doi: 10.1007/s00259-020-05088-z. Epub 2020 Nov 2.
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Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study.
应用 188 铼放射性敷贴治疗皮肤癌:一项长期回顾性研究
J Dermatolog Treat. 2022 Mar;33(2):969-975. doi: 10.1080/09546634.2020.1793890. Epub 2020 Jul 22.
4
European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention.欧洲多学科指南:侵袭性鳞状细胞皮肤癌——第 1 部分:流行病学、诊断和预防。
Eur J Cancer. 2020 Mar;128:60-82. doi: 10.1016/j.ejca.2020.01.007. Epub 2020 Feb 26.
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Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging.皮肤鳞状细胞癌:发病率、危险因素、诊断和分期。
J Am Acad Dermatol. 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059.
6
Dermo beta brachytherapy with 188-Re in squamous cell carcinoma of the penis: a new therapy.188Re 放射性胶体敷贴治疗阴茎鳞癌——一种新的治疗方法。
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7
Treatment of squamous cell carcinoma in situ: a review.治疗原位鳞状细胞癌:综述。
Dermatol Surg. 2011 Oct;37(10):1394-411. doi: 10.1111/j.1524-4725.2011.02088.x. Epub 2011 Jul 18.
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A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics.新版美国癌症联合委员会皮肤鳞状细胞癌分期系统:纳入肿瘤(T)特征的制定和原理。
J Am Acad Dermatol. 2011 Jun;64(6):1051-9. doi: 10.1016/j.jaad.2010.08.033. Epub 2011 Jan 20.
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