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共刺激作用克服了 CD8 T 细胞对广泛亲和力范围内恒定抗原输入的完美适应。

Perfect adaptation of CD8 T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.

机构信息

Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.

Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX1 3RE Oxford, UK.

出版信息

Sci Signal. 2021 Jan 19;14(666):eaay9363. doi: 10.1126/scisignal.aay9363. Epub 2021 Jul 15.

DOI:10.1126/scisignal.aay9363
PMID:34855472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7615691/
Abstract

Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.

摘要

相反，共刺激受体的信号可以挽救由对比抗原刺激引起的 T 细胞反应的降低。

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本文引用的文献

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Molecular mechanisms of T cell sensitivity to antigen.T 细胞对抗原敏感性的分子机制。
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An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity.基于抗体的MHC限制性嵌合抗原受体需要类似TCR的亲和力来维持抗原特异性。
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CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.慢性感染和癌症中的 CD8 T 细胞耗竭：干预的机会。
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Cell Biology of T Cell Receptor Expression and Regulation.T 细胞受体表达和调节的细胞生物学。
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