共刺激作用克服了 CD8 T 细胞对广泛亲和力范围内恒定抗原输入的完美适应。
Perfect adaptation of CD8 T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.
机构信息
Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX1 3RE Oxford, UK.
出版信息
Sci Signal. 2021 Jan 19;14(666):eaay9363. doi: 10.1126/scisignal.aay9363. Epub 2021 Jul 15.
Abstract
Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.
摘要
相反，共刺激受体的信号可以挽救由对比抗原刺激引起的 T 细胞反应的降低。
相似文献
1
Perfect adaptation of CD8 T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.共刺激作用克服了 CD8 T 细胞对广泛亲和力范围内恒定抗原输入的完美适应。
Sci Signal. 2021 Jan 19;14(666):eaay9363. doi: 10.1126/scisignal.aay9363. Epub 2021 Jul 15.
2
4-1BB costimulation promotes bystander activation of human CD8 T cells.4-1BB 共刺激促进人 CD8 T 细胞的旁观者激活。
Eur J Immunol. 2021 Mar;51(3):721-733. doi: 10.1002/eji.202048762. Epub 2020 Dec 23.
3
Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients.常见变异型免疫缺陷（CVID）患者的CD4 +和CD8 + T淋巴细胞中，源自T细胞受体（TCR）和共刺激分子的激活信号整合存在缺陷。
Clin Exp Immunol. 1997 Nov;110(2):174-81. doi: 10.1111/j.1365-2249.1997.tb08314.x.
4
CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation.CD28，CD8 T淋巴细胞激活的白细胞介素-2非依赖性共刺激途径。
J Immunol. 1999 Aug 1;163(3):1133-42.
5
NKG2D receptor activation of NF-κB enhances inflammatory cytokine production in murine effector CD8(+) T cells.NKG2D受体对核因子-κB的激活增强了小鼠效应性CD8(+) T细胞中炎性细胞因子的产生。
Mol Immunol. 2015 Feb;63(2):268-78. doi: 10.1016/j.molimm.2014.07.015. Epub 2014 Jul 31.
6
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.4-1BB共刺激信号优先诱导CD8 + T细胞增殖，并导致体内细胞毒性T细胞反应的扩增。
J Exp Med. 1997 Jul 7;186(1):47-55. doi: 10.1084/jem.186.1.47.
7
Enhancement of HIV-specific CD8 T cell responses by dual costimulation with CD80 and CD137L.通过CD80和CD137L双重共刺激增强HIV特异性CD8 T细胞反应。
J Immunol. 2005 Nov 15;175(10):6378-89. doi: 10.4049/jimmunol.175.10.6378.
8
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response.关于CD28/CD40配体共刺激、共同γ链信号及同种免疫反应。
J Immunol. 2002 May 1;168(9):4382-90. doi: 10.4049/jimmunol.168.9.4382.
9
Antigen-presenting cells containing multiple costimulatory molecules promote activation and expansion of human antigen-specific memory CD8+ T cells.含有多种共刺激分子的抗原呈递细胞可促进人抗原特异性记忆CD8+T细胞的活化和扩增。
Cancer Immunol Immunother. 2009 Apr;58(4):503-15. doi: 10.1007/s00262-008-0572-8. Epub 2008 Aug 9.
10
A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells.一条防止CD28阴性T细胞无反应性的共刺激途径：CD1限制性T细胞的不依赖B7的共刺激。
J Exp Med. 1995 Dec 1;182(6):2007-18. doi: 10.1084/jem.182.6.2007.
引用本文的文献
1
Cumulative dose responses for adapting biological systems.生物系统适应性的累积剂量反应。
J R Soc Interface. 2025 Aug;22(229):20240877. doi: 10.1098/rsif.2024.0877. Epub 2025 Aug 13.
2
Tumor cell spheroid-induced suppression of primary human cytotoxic T cells as a scalable model of exhaustion.肿瘤细胞球体诱导的原代人细胞毒性T细胞抑制作为一种可扩展的耗竭模型。
Immunother Adv. 2025 Jun 11;5(1):ltaf023. doi: 10.1093/immadv/ltaf023. eCollection 2025.
3
Platforms for studying cell-cell recognition by immune cells.用于研究免疫细胞间细胞识别的平台。
Immunol Cell Biol. 2025 Aug;103(7):636-647. doi: 10.1111/imcb.70036. Epub 2025 May 29.
4
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells.共刺激受体对TCR-T细胞中细胞因子产生时间的调节在CAR-T细胞中丧失。
Immunother Adv. 2024 Jun 19;4(1):ltae004. doi: 10.1093/immadv/ltae004. eCollection 2024.
5
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors.利用 CombiCells 平台进行细胞表面配体的滴定和组合展示，研究辅助受体对 T 细胞抗原敏感性的调节。
EMBO J. 2024 Jan;43(1):132-150. doi: 10.1038/s44318-023-00012-1. Epub 2023 Dec 18.
6
Antigen perception in T cells by long-term Erk and NFAT signaling dynamics.T 细胞中通过长期 Erk 和 NFAT 信号动态感知抗原。
Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2308366120. doi: 10.1073/pnas.2308366120. Epub 2023 Dec 19.
7
Tregs with an MHC class II peptide-specific chimeric antigen receptor prevent autoimmune diabetes in mice.嵌合抗原受体识别 MHC Ⅱ类肽的调节性 T 细胞可预防小鼠自身免疫性糖尿病。
J Clin Invest. 2023 Sep 15;133(18):e168601. doi: 10.1172/JCI168601.
8
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.辅助受体利用效率低下降低了嵌合抗原受体的敏感性。
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2216352120. doi: 10.1073/pnas.2216352120. Epub 2023 Jan 4.
9
Cellular kinetics: A clinical and computational review of CAR-T cell pharmacology.细胞动力学：CAR-T 细胞药理学的临床和计算综述。
Adv Drug Deliv Rev. 2022 Sep;188:114421. doi: 10.1016/j.addr.2022.114421. Epub 2022 Jul 6.
10
B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?嵌合抗原受体 T 细胞疗法中的 B 细胞靶向：是 CAR T 细胞功能的副作用还是驱动因素？
Sci Transl Med. 2022 Jun 22;14(650):eabn3353. doi: 10.1126/scitranslmed.abn3353.
本文引用的文献
1
Molecular mechanisms of T cell sensitivity to antigen.T 细胞对抗原敏感性的分子机制。
Immunol Rev. 2018 Sep;285(1):194-205. doi: 10.1111/imr.12690.
2
An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity.基于抗体的MHC限制性嵌合抗原受体需要类似TCR的亲和力来维持抗原特异性。
Mol Ther Oncolytics. 2017 Jan 11;3:1-9. doi: 10.1038/mto.2016.23. eCollection 2016.
3
CAR T cell immunotherapy for human cancer.嵌合抗原受体 T 细胞免疫疗法治疗人类癌症。
Science. 2018 Mar 23;359(6382):1361-1365. doi: 10.1126/science.aar6711.
4
CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.慢性感染和癌症中的 CD8 T 细胞耗竭：干预的机会。
Annu Rev Med. 2018 Jan 29;69:301-318. doi: 10.1146/annurev-med-012017-043208.
5
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression.脱敏嵌合抗原受体T细胞选择性识别抗原表达增强的靶细胞。
Nat Commun. 2018 Feb 1;9(1):468. doi: 10.1038/s41467-018-02912-x.
6
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains.同种识别域的人 TCRs 和 CARs 介导的 T 细胞活性比较。
J Immunol. 2018 Feb 1;200(3):1088-1100. doi: 10.4049/jimmunol.1700236. Epub 2017 Dec 29.
7
Cell Biology of T Cell Receptor Expression and Regulation.T 细胞受体表达和调节的细胞生物学。
Annu Rev Immunol. 2018 Apr 26;36:103-125. doi: 10.1146/annurev-immunol-042617-053429. Epub 2017 Dec 20.
8
Oscillatory stimuli differentiate adapting circuit topologies.振荡刺激可区分适应性电路拓扑结构。
Nat Methods. 2017 Oct;14(10):1010-1016. doi: 10.1038/nmeth.4408. Epub 2017 Aug 28.
9
Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8 T cells.不同的蛋白激酶 C 介导的转录后事件设定了 CD8 T 细胞细胞因子产生的动力学。
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9677-9682. doi: 10.1073/pnas.1704227114. Epub 2017 Aug 23.
10
Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia.抗CD123嵌合抗原受体结合亲和力与密度的平衡对急性髓系白血病的靶向作用
Mol Ther. 2017 Aug 2;25(8):1933-1945. doi: 10.1016/j.ymthe.2017.04.017. Epub 2017 May 4.
Zotero 插件