Castro-Calderón Adriana, Roccuzzo Andrea, Ferrillo Martina, Gada Sneha, González-Serrano José, Fonseca Manrique, Molinero-Mourelle Pedro
Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, Spain.
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Acta Odontol Scand. 2022 May;80(4):295-307. doi: 10.1080/00016357.2021.2007282. Epub 2021 Dec 2.
To assess the efficacy and safety of hyaluronic acid (HA) injections to restore the lost interproximal papilla.
A systematic literature search was conducted in PubMed/MEDLINE, Scopus and Cochrane electronic databases with no time restriction up to September 2021. Any clinical study evaluating HA injection into the interproximal papilla loss Class I and II according to Norland & Tarnow, were included based on the following PICO questions (1) Are HA injections effective for the reconstruction of the interproximal papilla loss? (2) What are the side/adverse effects of using HA for the reconstruction of interproximal papilla loss? The risk of bias assessment was performed using the Cochrane Collaboration's the Newcastle Ottawa and Joanna Briggs institute tools.
A total of 1497 titles were retrieved. From these, eleven were included and underwent full data extraction. However, due to heterogeneity in the data among the included articles, a meta-analysis could not be performed. Three articles reported no-differences in term of papilla tip to contact point distance or the papilla fill reduction. Finally, five studies showed a reduction in the black triangle with a percentage range between 19 and 47%.
The non-surgical use of HA injection seems to have a positive effect on the re-establishment of interproximal papilla lost. However post-operative complications might develop.
评估透明质酸（HA）注射恢复缺失的邻间乳头的疗效和安全性。
在PubMed/MEDLINE、Scopus和Cochrane电子数据库中进行了无时间限制直至2021年9月的系统文献检索。根据以下PICO问题纳入任何评估按照Norland和Tarnow分类的I类和II类邻间乳头缺失注射HA的临床研究：（1）HA注射对重建邻间乳头缺失是否有效？（2）使用HA重建邻间乳头缺失的副作用/不良反应有哪些？使用Cochrane协作网的纽卡斯尔渥太华工具和乔安娜·布里格斯研究所工具进行偏倚风险评估。
共检索到1497个标题。其中，11篇被纳入并进行了完整的数据提取。然而，由于纳入文章之间数据的异质性，无法进行荟萃分析。3篇文章报告在乳头尖端到接触点距离或乳头填充减少方面无差异。最后，5项研究显示黑色三角减少，减少百分比范围在19%至47%之间。
非手术使用HA注射似乎对重建缺失的邻间乳头有积极作用。然而，可能会出现术后并发症。
