Oral Health Prev Dent. 2022 Nov 8;20:421-431. doi: 10.3290/j.ohpd.b3556037.
The aim of this review is to analyse the use of hyaluronic acid injection in the interdental space to reconstruct the papilla in animal models and humans.
Electronic databases were searched up to May 2022, and additional hand searching was performed. The search strategy was implemented according to the PRISMA guidelines. The inclusion criteria were: studies written in English, studies using hyaluronic acid, in vivo studies, studies with a precise number of specimens, case series with ≥6 patients, and studies published after 2010. The risk of bias was assessed for each study that could be evaluated.
A total of 19 articles were selected and reviewed in this review. Due to the great heterogeneity of the protocols and materials, comparison between studies was not possible. However, using this technique, the studies found statistically significant improvements in most cases. The filling percentages ranged from 19% to 100%. Regarding patient satisfaction, the few studies that evaluated this parameter found statistically significant results with most patients willing to repeat the experience. Regarding side effects, only two studies reported them. Moreover, the procedure does not seem to be very painful.
The results suggest that hyaluronic acid injections seem to be effective in reconstructing papillary volume. However, to date, too few clinical trials with a high level of proof have been conducted on this technique. Future studies will have to work on the size of the sample, the concentration of the product, the number of injections and the injection method.
本综述旨在分析在动物模型和人类中使用透明质酸注射到牙间隙中以重建乳头的用途。
截至 2022 年 5 月，我们对电子数据库进行了搜索，并进行了额外的手工搜索。搜索策略是根据 PRISMA 指南实施的。纳入标准为：英文书写的研究、使用透明质酸的研究、体内研究、有明确标本数量的研究、有≥6 例患者的病例系列研究、以及发表于 2010 年以后的研究。对每一项可评估的研究进行偏倚风险评估。
本综述共选择并回顾了 19 篇文章。由于方案和材料的高度异质性，研究之间无法进行比较。然而，使用这种技术，大多数情况下研究发现了统计学上的显著改善。填充百分比从 19%到 100%不等。关于患者满意度，少数评估该参数的研究发现，大多数患者愿意重复该体验，其结果具有统计学意义。关于副作用，只有两项研究报告了副作用。此外，该操作似乎不是很痛苦。
结果表明，透明质酸注射似乎可有效重建乳头体积。然而，迄今为止，对于这种技术，仅有少量具有较高证据水平的临床试验。未来的研究将必须研究样本量、产品浓度、注射次数和注射方法。
