Taylor A M, Butterworth S V
Int J Cancer. 1986 Apr 15;37(4):511-6. doi: 10.1002/ijc.2910370407.
Ataxia telangiectasia (A-T) is an autosomal recessive disorder in which patients show an unusual predisposition to malignant disease, including T-cell chronic lymphocytic leukaemia. We report here the steady growth over 5 years of a complex, cytogenetically abnormal clone of T lymphocytes in an A-T patient who was subsequently found to have an OKT3/OKT8 chronic lymphocytic leukaemia. The tumour cells at diagnosis had clearly evolved from a pre-existing, cytogenetically abnormal T-cell clone which contained an inv(14) chromosomal inversion alone.
共济失调毛细血管扩张症（A-T）是一种常染色体隐性疾病，患者表现出对恶性疾病的异常易感性，包括T细胞慢性淋巴细胞白血病。我们在此报告，一名A-T患者体内一个复杂的、细胞遗传学异常的T淋巴细胞克隆在5年中持续生长，该患者随后被发现患有OKT3/OKT8慢性淋巴细胞白血病。诊断时的肿瘤细胞显然是从一个预先存在的、细胞遗传学异常的T细胞克隆演变而来，该克隆仅含有一个inv(14)染色体倒位。
