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尼日利亚农村青光眼患者的患病率及临床特征——一项基于医院的研究

Prevalence and clinical profile of glaucoma patients in rural Nigeria-A hospital based study.

作者信息

Ezinne Ngozika E, Ojukwu Chukwuebuka S, Ekemiri Kingsley K, Akano Obinna F, Ekure Edgar, Osuagwu Uchechukwu Levi

机构信息

Department of Clinical Surgical Sciences, Optometry Unit, University of the West Indies, St Augustine Campus, Trinidad and Tobago.

Department of Optometry, Madonna University, Elele campus, Okija, Nigeria.

出版信息

PLoS One. 2021 Dec 2;16(12):e0260965. doi: 10.1371/journal.pone.0260965. eCollection 2021.

Abstract

PURPOSE

To determine the prevalence and clinical presentation of participants with glaucoma attending a public eye care facility in Nigeria.

METHOD

Hospital based retrospective study of glaucoma participants aged 50 years and above seen over a 5-year period. Descriptive statistics summarized the demographic, clinical characteristics and treatment of the participants and determined the association of variables with gender and age. Prevalence of the glaucoma by type, and their 95% confidence intervals (CI) were also calculated.

RESULT

Of the 5482 case files that were reviewed, 995 (18.15%, 95% Cl 17.15-19.19%) had glaucoma particularly primary open angle glaucoma (11.55%, 95%CI 10.73-12.42%) and were mostly females (564, 56.7%) aged 69 ± 12 years (range, 50-103 years). In contrast to other glaucoma types, the prevalence of primary angle closure glaucoma (3.68, 95%CI 3.22-4.22) increased by 15% over 5 years. The mean intraocular pressure ranged from 15-50 mmHg but higher in females than males (27.8 ± 6.1mmHg versus 26.6 ± 6.0 mmHg, P <0.05) who had comparable VA (0.58 ± 0.4 Log MAR) and cup-disc ratios (P >0.05). On presentation, the glaucoma hemi field test (GHFT) was outside the normal limits in 45.5% and 54.5% of males and females, respectively. The type of visual field defect was associated with glaucoma type (P = 0.047). Arcuate scotoma was most common (35.5%) across glaucoma types, paracentral scotoma more common in Secondary glaucoma while Seidel scotoma was highest in NTG (19.3%). Beta-blocker was the mainstay of management (42.2%) but more likely to be prescribed to males while more females received carbonic anhydrase inhibitors.

CONCLUSIONS

The high prevalence of glaucoma in older people remains a public health problem in Nigeria. The fact that about half of the participants presented with visual field defect suggests there is a need for public health messages to emphasize on early glaucoma screening, detection and management.

摘要

目的

确定在尼日利亚一家公共眼科护理机构就诊的青光眼患者的患病率及临床表现。

方法

对50岁及以上青光眼患者进行为期5年的基于医院的回顾性研究。描述性统计总结了患者的人口统计学、临床特征及治疗情况,并确定变量与性别和年龄的关联。还计算了各类型青光眼的患病率及其95%置信区间(CI)。

结果

在审查的5482份病例档案中,995例(18.15%,95%CI 17.15 - 19.19%)患有青光眼,尤其是原发性开角型青光眼(11.55%,95%CI 10.73 - 12.42%),且大多为女性(564例,56.7%),年龄为69±12岁(范围50 - 103岁)。与其他青光眼类型不同,原发性闭角型青光眼的患病率(3.68,95%CI 3.22 - 4.22)在5年内上升了15%。平均眼压范围为15 - 50 mmHg,但女性高于男性(27.8±6.1 mmHg对26.6±6.0 mmHg,P<0.05),而视力(VA)(0.58±0.4 Log MAR)和杯盘比相当(P>0.05)。初诊时,青光眼半视野检测(GHFT)在男性和女性中分别有45.5%和54.5%超出正常范围。视野缺损类型与青光眼类型相关(P = 0.047)。弓形暗点在各类型青光眼中最为常见(35.5%),旁中心暗点在继发性青光眼中更常见,而塞德尔暗点在正常眼压性青光眼中最高(19.3%)。β受体阻滞剂是主要治疗手段(42.2%),但更可能开给男性,而更多女性接受碳酸酐酶抑制剂治疗。

结论

青光眼在尼日利亚老年人中的高患病率仍是一个公共卫生问题。约半数患者出现视野缺损这一事实表明,需要通过公共卫生宣传来强调青光眼的早期筛查、检测及管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/8639068/26bfabfb9341/pone.0260965.g001.jpg

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