Gumrich K, Virsik-Peuckert R P, Harder D
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Apr;49(4):665-72. doi: 10.1080/09553008514552911.
Irradiation temperature, changed from 37 degrees C to 4 degrees C, acts as a dose-modifying factor with regard to the dose-yield relationship for dicentric chromosome aberrations in human lymphocytes irradiated with 150 kV X-rays. The temperature dependence of the aberration yield observed at constant dose is S-shaped, with a sharp rise near 15 degrees C from a lower plateau below 12 degrees C to a higher plateau beyond 17 degrees C. The aberration yield is determined by the irradiation temperature, irrespective of fast temperature changes from 4 degrees C to 37 degrees C or from 37 degrees C to 4 degrees C, applied at various delay times before and after irradiation. It is concluded that irradiation temperature influences the formation of chromatin lesions rather than their interaction.
照射温度从37摄氏度变为4摄氏度时，对于用150 kV X射线照射的人淋巴细胞中的双着丝粒染色体畸变，它是剂量-产额关系的剂量修正因子。在恒定剂量下观察到的畸变产额的温度依赖性呈S形，在15摄氏度附近从12摄氏度以下的较低平稳期急剧上升到17摄氏度以上的较高平稳期。畸变产额由照射温度决定，与在照射前后不同延迟时间施加的从4摄氏度到37摄氏度或从37摄氏度到4摄氏度的快速温度变化无关。得出的结论是，照射温度影响染色质损伤的形成而非其相互作用。
