Virsik-Peuckert R P, Harder D
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Apr;49(4):673-81. doi: 10.1080/09553008514552921.
Dicentric chromosome aberration yields have been measured after single-exposure and split-dose irradiations of human lymphocytes with 150 kV X-rays. Various temperature programmes between 4 and 37 degrees C were applied before, during and after irradiations and in the radiation-free interval. It was found that chromatin lesion repair was completely suppressed at 21 degrees C and below, whereas lesion formation is reduced only below 17 degrees C. The interaction between repairable lesions which leads to exchange-type aberrations is also suppressed by low temperatures. Hypothermic suppression of chromatin lesion repair and interaction is fully reversible at least up to 12 h of maintenance of the 'stored' state of these lesions.
用150 kV X射线对人淋巴细胞进行单次照射和分次照射后，已测量了双着丝粒染色体畸变率。在照射前、照射期间、照射后以及无辐射间隔期，采用了4至37摄氏度之间的各种温度程序。结果发现，在21摄氏度及以下时，染色质损伤修复被完全抑制，而损伤形成仅在17摄氏度以下才减少。导致交换型畸变的可修复损伤之间的相互作用也受到低温抑制。染色质损伤修复和相互作用的低温抑制至少在维持这些损伤的“储存”状态长达12小时时是完全可逆的。
